Progressive gammopathy and coagulopathy in a young English bulldog.

Jennifer L Grady, Anne Avery, A Russell Moore, Lauren J Harris, Neketa Kakar, Emily D Rout

Open access · greenAbstract readCase Reports

In one paragraph

Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 98% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jennifer L GradyTufts University, Cummings School of Veterinary Medicine, Department of Clinical Sciences, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Grady, Kakar); Colorado State University, College of Veterinary Medicine and Biomedical Science, Department of Microbiology, Immunology, and Pathology, 200 West Lake Street, Fort Collins, Colorado 80523 USA (Avery, Moore, Harris, Rout).

Anne AveryTufts University, Cummings School of Veterinary Medicine, Department of Clinical Sciences, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Grady, Kakar); Colorado State University, College of Veterinary Medicine and Biomedical Science, Department of Microbiology, Immunology, and Pathology, 200 West Lake Street, Fort Collins, Colorado 80523 USA (Avery, Moore, Harris, Rout).

A Russell MooreTufts University, Cummings School of Veterinary Medicine, Department of Clinical Sciences, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Grady, Kakar); Colorado State University, College of Veterinary Medicine and Biomedical Science, Department of Microbiology, Immunology, and Pathology, 200 West Lake Street, Fort Collins, Colorado 80523 USA (Avery, Moore, Harris, Rout).

Lauren J HarrisTufts University, Cummings School of Veterinary Medicine, Department of Clinical Sciences, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Grady, Kakar); Colorado State University, College of Veterinary Medicine and Biomedical Science, Department of Microbiology, Immunology, and Pathology, 200 West Lake Street, Fort Collins, Colorado 80523 USA (Avery, Moore, Harris, Rout).

Neketa KakarTufts University, Cummings School of Veterinary Medicine, Department of Clinical Sciences, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Grady, Kakar); Colorado State University, College of Veterinary Medicine and Biomedical Science, Department of Microbiology, Immunology, and Pathology, 200 West Lake Street, Fort Collins, Colorado 80523 USA (Avery, Moore, Harris, Rout).

Emily D RoutTufts University, Cummings School of Veterinary Medicine, Department of Clinical Sciences, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Grady, Kakar); Colorado State University, College of Veterinary Medicine and Biomedical Science, Department of Microbiology, Immunology, and Pathology, 200 West Lake Street, Fort Collins, Colorado 80523 USA (Avery, Moore, Harris, Rout).

Tufts University · US

Funding

Biomedical Research Training for VeterinariansT32OD010437 · OD · COLORADO STATE UNIVERSITY · PI Gregg A Dean, KELLY S SANTANGELO · 2012 to 2026

$6.2M

NIH HHS T32 OD010437

6 · The paper itself

Abstract

A restricted polyclonal or biclonal gammopathy resulting in bleeding tendencies was diagnosed in a young, neutered male English bulldog with concurrent splenomegaly, anemia, and severe elevations in IgM and, to a lesser degree, IgA immunoglobulins. There was a positive clinical response to treatment with prednisone and chlorambucil. This case bears similarity to a recently published syndrome of polyclonal gammopathy that is not neoplastic in origin in this breed. Key clinical message: The current case describes the management and clinical course of a recently described syndrome of polyclonal gammopathy in English bulldogs.

Indexed as

Dog DiseasesParaproteinemiasAnimalsDogsHypergammaglobulinemiaMale

Identifiers

PMID33542555

PMCPMC7808204

OpenAlexW3127015745

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.