Evidence map›Paper›PMID 33542478›Full record

ArticleJournal of exposure science & environmental epidemiology2021

Per- and polyfluoroalkyl substances (PFAS) and total fluorine in fire station dust.

Anna S Young, Emily H Sparer-Fine, Heidi M Pickard, Elsie M Sunderland, Graham F Peaslee, Joseph G Allen

Registry-linked trialAbstract read
In one paragraph

Article in Journal of exposure science & environmental epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07226440 (Assessing the Impact of a Bile Acid Sequestrant on Serum PFAS Levels in Highly Exposed Individuals), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07226440 phase1 / phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Assessing the Impact of a Bile Acid Sequestrant on Serum PFAS Levels in Highly Exposed Individuals

TypeinterventionalSponsorUniversity of California, San FranciscoRan2026 to 2028Enrolled50ConditionsToxicant Exposure, Firefighter, Occupational Exposure to ChemicalsArmsColesevelam, Placebo
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Serum PFAS levels in UK firefighters.Scientific reports · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The impact of particle size on PFAS concentrations in dust from homes in North Carolina and New York and implications for exposure.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2026
    Article
  9. Article
  10. Article
  11. Indoor air concentrations of PMEnvironmental science. Processes & impacts · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Systemic and immunotoxicity induced by topical application of perfluorohexane sulfonic acid (PFHxS) in a murine model.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anna S YoungHarvard T.H. Chan School of Public Health, Boston, MA, USA. ayoung@mail.harvard.edu.ORCID http://orcid.org/0000-0002-6047-4406
Emily H Sparer-FineHarvard T.H. Chan School of Public Health, Boston, MA, USA.
Heidi M PickardHarvard Graduate School of Arts and Sciences, Cambridge, MA, USA.
Elsie M SunderlandHarvard T.H. Chan School of Public Health, Boston, MA, USA.
Graham F PeasleeDepartment of Physics, University of Notre Dame, Notre Dame, IN, USA.
Joseph G AllenHarvard T.H. Chan School of Public Health, Boston, MA, USA.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
The HSPH Education and Research Center of Occupational Safety and HealthT42OH008416 · OH · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTIANI, DAVID C · 2005 to 2025
$30.5M
Sources, Transport, Exposure & Effects of PFAS (STEEP) Center - RENEWALP42ES027706 · NIEHS · UNIVERSITY OF RHODE ISLAND · PI Harrison Dekker · 2017 to 2026
$18.9M
Training Program in Environmental EpidemiologyT32ES007069 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LADEN, FRANCINE · 1985 to 2024
$13.9M
ACL HHS T42OH008416NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P42 ES027706NIEHS NIH HHS T32 ES007069NIOSH CDC HHS T42 OH008416
6 · The paper itself

Abstract

Per- and polyfluoroalkyl substances (PFAS) are a class of over 4700 fluorinated compounds used in industry and consumer products. Studies have highlighted the use of aqueous film-forming foams (AFFFs) as an exposure source for firefighters, but little is known about PFAS occurrence inside fire stations, where firefighters spend most of their shifts. In this study, we aimed to characterize PFAS concentrations and sources inside fire stations. We measured 24 PFAS (using LC-MS/MS) and total fluorine (using particle-induced gamma ray emission) in dust from multiple rooms of 15 Massachusetts stations, many of which (60%) no longer use PFAS-containing AFFF at all and the rest of which only use it very rarely. Compared to station living rooms, turnout gear locker rooms had higher dust levels of total fluorine (p < 0.0001) and three PFAS: perfluorohexanoate (PFHxA), perfluoroheptanoate (PFHpA), and perfluorodecanoate (PFDoDA) (p < 0.05). These PFAS were also found on six wipes of station turnout gear. By contrast, the dominant PFAS in living rooms was N-ethyl perfluorooctane sulfonamidoacetic acid (N-MeFOSAA), a precursor to perfluorooctane sulfonate (PFOS) that still persists despite phase-outs almost two decades ago. The Σ

Indexed as

Alkanesulfonic AcidsFluorocarbonsWater Pollutants, ChemicalChromatography, LiquidDustFluorineHumansTandem Mass SpectrometryAlkanesulfonic AcidsDustFluorineFluorocarbonsWater Pollutants, ChemicalAnalytical MethodsEmerging ContaminantsEndocrine DisruptorsHealthy BuildingsPerfluorinated ChemicalsPFASVulnerable OccupationsWorkplace Exposures

Identifiers

PMID33542478
PMCPMC8339150

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.