Evidence map›Paper›PMID 33542415›Full record

ArticleScientific reports2021

Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies.

Cristian Carmeli, Zoltán Kutalik, Pashupati P Mishra, Eleonora Porcu, Cyrille Delpierre, Olivier Delaneau, Michelle Kelly-Irving, Murielle Bochud, Nasser A Dhayat, Belen Ponte and 11 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Pooled it
  2. Article
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  5. Three common assumptions about inflammation, aging, and health that are probably wrong.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 13 institutions in 4 countries.

Cristian CarmeliPopulation Health Laboratory (#PopHealthLab), University of Fribourg, Route des Arsenaux 41, 1700, Fribourg, Switzerland. cristian.carmeli@unifr.ch.
Zoltán KutalikCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Pashupati P MishraDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center, Faculty of Medicine and Health Technology, Tampere University, 33520, Tampere, Finland.
Eleonora PorcuCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Cyrille DelpierreUMR1027, Toulouse III University, Inserm, Toulouse, France.
Olivier DelaneauDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Michelle Kelly-IrvingUMR1027, Toulouse III University, Inserm, Toulouse, France.
Murielle BochudCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Nasser A DhayatDepartment of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Belen PonteService of Nephrology, Geneva University Hospitals, Geneva, Switzerland.
Menno PruijmService of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Georg EhretDepartment of Cardiology, Geneva University Hospital, Geneva, Switzerland.
Mika KähönenDepartment of Clinical Physiology, Fimlab Laboratories, and Finnish Cardiovascular Research Center, Faculty of Medicine and Health Technology, Tampere University, 33521, Tampere, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center, Faculty of Medicine and Health Technology, Tampere University, 33520, Tampere, Finland.
Olli T RaitakariCentre for Population Health Research, University of Turku, Turku University Hospital, Turku, Finland.
Paolo VineisMRC Centre for Environment and Health, School of Public Health, Imperial College London, London, W21PG, UK.
Mika KivimäkiDepartment of Epidemiology and Public Health, University College London, London, UK.
Marc Chadeau-HyamMRC Centre for Environment and Health, School of Public Health, Imperial College London, London, W21PG, UK.
Emmanouil DermitzakisDepartment of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.
Nicolas VuilleumierDivision of Laboratory Medicine, Geneva University Hospital, Geneva, Switzerland.
Silvia StringhiniCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
University Hospital of Geneva · CHUniversity of Lausanne · CHCentre universitaire de médecine générale et santé publique, Lausanne · CHFimlab (Finland) · FIImperial College London · GBInserm · FRTampere University · FITurku University Hospital · FIUniversité Fédérale de Toulouse Midi-Pyrénées · FRUniversity College London · GBUniversity Hospital of Bern · CHUniversity of Fribourg · CHUniversity of Geneva · CH

Funding

Education, socioeconomic status and Aging: transitions from multimorbidity to functional limitations and mortalityR01AG056477 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2018 to 2022
$2.8M
Medical Research Council MR/R024227/1Medical Research Council MR/S011676/1Medical Research Council MR/S019669/1NIA NIH HHS R01 AG056477
6 · The paper itself

Abstract

Individuals experiencing socioeconomic disadvantage in childhood have a higher rate of inflammation-related diseases decades later. Little is known about the mechanisms linking early life experiences to the functioning of the immune system in adulthood. To address this, we explore the relationship across social-to-biological layers of early life social exposures on levels of adulthood inflammation and the mediating role of gene regulatory mechanisms, epigenetic and transcriptomic profiling from blood, in 2,329 individuals from two European cohort studies. Consistently across both studies, we find transcriptional activity explains a substantive proportion (78% and 26%) of the estimated effect of early life disadvantaged social exposures on levels of adulthood inflammation. Furthermore, we show that mechanisms other than cis DNA methylation may regulate those transcriptional fingerprints. These results further our understanding of social-to-biological transitions by pinpointing the role of gene regulation that cannot fully be explained by differential cis DNA methylation.

Indexed as

Epigenesis, GeneticTranscriptomeAdultAgedAged, 80 and overBiomarkersChildC-Reactive ProteinDNA MethylationFemaleFinlandGene Expression ProfilingHumansImmune SystemInflammationLife Change EventsBiomarkersC-Reactive Protein

Identifiers

PMID33542415
PMCPMC7862626
OpenAlexW3127153307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.