Evidence map›Paper›PMID 33542389›Full record

ArticleScientific reports2021

White matter of perinatally HIV infected older youths shows low frequency fluctuations that may reflect glial cycling.

Manoj K Sarma, Amrita Pal, Margaret A Keller, Tamara Welikson, Joseph Ventura, David E Michalik, Karin Nielsen-Saines, Jaime Deville, Andrea Kovacs, Eva Operskalski and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Manoj K SarmaDepartment of Radiological Sciences, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA, 90095-1721, USA.
Amrita PalUCLA School of Nursing, University of California, Los Angeles, Los Angeles, CA, USA.
Margaret A KellerPediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.
Tamara WeliksonPsychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Joseph VenturaPsychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
David E MichalikInfectious Diseases-Pediatrics, Miller Children's Hospital of Long Beach, Long Beach, CA, USA.
Karin Nielsen-SainesDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Jaime DevilleDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Andrea KovacsKeck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Eva OperskalskiKeck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Joseph A ChurchPediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Paul M MaceyUCLA School of Nursing, University of California, Los Angeles, Los Angeles, CA, USA.
Bharat BiswalBiomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA.
M Albert ThomasDepartment of Radiological Sciences, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA, 90095-1721, USA. AThomas@mednet.ucla.edu.
University of California, Los Angeles · USLAC+USC Medical Center · USNeurobehavioral Systems · USHarbor–UCLA Medical Center · USMiller Children's & Women's Hospital · USNew Jersey Institute of Technology · USUniversity of Southern California · US

Funding

Brain Connectivity, Cerebral metabolism and Neuropsychology in HIV YouthsR21NS090956 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SARMA, MANOJ KUMAR · 2015 to 2016
$377k
NINDS NIH HHS R21 NS090956
6 · The paper itself

Abstract

In perinatally HIV-infected (PHIV) children, neurodevelopment occurs in the presence of HIV-infection, and even with combination antiretroviral therapy (cART) the brain can be a reservoir for latent HIV. Consequently, patients often demonstrate long-term cognitive deficits and developmental delay, which may be reflected in altered functional brain activity. Our objective was to examine brain function in PHIV on cART by quantifying the amplitude of low frequency fluctuations (ALFF) and regional homogeneity (ReHo). Further, we studied ALFF and ReHo changes with neuropsychological performance and measures of immune health including CD4 count and viral loads in the HIV-infected youths. We found higher ALFF and ReHo in cerebral white matter in the medial orbital lobe for PHIV (N = 11, age mean ± sd = 22.5 ± 2.9 years) compared to controls (N = 16, age = 22.5 ± 3.0 years), with age and gender as co-variates. Bilateral cerebral white matter showed increased spontaneous regional activity in PHIV compared to healthy controls. No brain regions showed lower ALFF or ReHo in PHIV compared to controls. Higher log10 viral load was associated with higher ALFF and ReHo in PHIV in bilateral cerebral white matter and right cerebral white matter respectively after masking the outcomes intrinsic to the brain regions that showed significantly higher ALFF and ReHo in the PHIV compared to the control. Reductions in social cognition and abstract thinking in PHIV were correlated with higher ALFF at the left cerebral white matter in the left medial orbital gyrus and higher ReHo at the right cerebral white matter in the PHIV patients. Although neuroinflammation and associated neuro repair were not directly measured, the findings support their potential role in PHIV impacting neurodevelopment and cognition.

Indexed as

AdolescentAdultBrainBrain MappingChildCognition DisordersCognitive DysfunctionFemaleHIV-1HIV InfectionsHumansInfectious Disease Transmission, VerticalMagnetic Resonance ImagingMaleNeurogliaViral Load

Identifiers

PMID33542389
PMCPMC7862588
OpenAlexW3127569663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.