ArticleScientific reports2021
Sequence characterisation and novel insights into bovine mastitis-associated Streptococcus uberis in dairy herds.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Genomic analysis of prophage prevalence and diversity in the bovine mastitis pathogenMicrobial genomics · 2026Article
- Molecular and phenotypic characterization ofMicrobiology spectrum · 2026Article
- Incidence of Streptococcus spp. and whole genome sequencing of Streptococcus agalactiae isolated from cow's milk samples in Brazil.Veterinary research communications · 2026Article
- Recombination, mobile genetic elements, and genetic transfer contribute to the adaptation of Streptococcus uberis causing mastitis.Veterinary research · 2026Article
- Article
- Draft genomes of two Streptococcus agalactiae from bovine mastitis in the North-West Province, South Africa.BMC genomic data · 2025Article
- Genomic Characterization and Antimicrobial Resistance Profile ofAntibiotics (Basel, Switzerland) · 2025Article
- Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.Open veterinary journal · 2025Review
- Global analysis of the genomic diversity, antimicrobial resistance and potential vaccine candidates carried by the major global bovine pathogenMicrobial genomics · 2025Article
- Whole-Genome Sequencing Analysis Revealed High Genomic Variability, Recombination Events and Mobile Genetic Elements inAntibiotics (Basel, Switzerland) · 2025Article
- Article
- Recent development and fighting strategies for lincosamide antibiotic resistance.Clinical microbiology reviews · 2024Review
- Antimicrobial resistance patterns of Streptococcus uberis isolates from bovine milk in Chiba prefecture, Japan: association between multidrug resistance and clonal complex 996.The Journal of veterinary medical science · 2024Article
- Genome analysis of Streptococcus spp. isolates from animals in pre-antibiotic era with respect to antibiotic susceptibility and virulence gene profiles.Veterinary research · 2024Article
- A core genome multi-locus sequence typing scheme forMicrobial genomics · 2024Article
- Survey of Genotype Diversity, Virulence, and Antimicrobial Resistance Genes in Mastitis-CausingPathogens (Basel, Switzerland) · 2023Article
- Antimicrobial Susceptibility and Resistance Genes inAntibiotics (Basel, Switzerland) · 2023Article
- Diversity ofFrontiers in veterinary science · 2023Article
- Multilocus Sequence Genotype Heterogeneity inAnimals : an open access journal from MDPI · 2022Article
- Genomic surveillance reveals antibiotic resistance gene transmission via phage recombinases within sheep mastitis-associated Streptococcus uberis.BMC veterinary research · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus uberis is one of the most frequent mastitis-causing pathogens isolated from dairy cows. Further understanding of S. uberis genetics may help elucidate the disease pathogenesis. We compared the genomes of S. uberis isolates cultured from dairy cows located in distinctly different geographic regions of Australia. All isolates had novel multi locus sequence types (MLST) indicating a highly diverse population of S. uberis. Global clonal complexes (GCC) were more conserved. GCC ST86 and GCC ST143 represented 30% of the total isolates (n = 27) and were clustered within different geographic regions. Core genome phylogeny revealed low phylogenetic clustering by region, isolation source, and MLST. Identification of putative sortase (srtA) substrates and generation of a custom putative virulence factor database revealed genes which may explain the affinity of S. uberis for mammary tissue, evasion of antimicrobial efforts and disease pathogenesis. Of 27 isolates, four contained antibiotic resistance genes including an antimicrobial resistance cluster containing mel/mef(A), mrsE, vatD, lnuD, and transposon-mediated lnuC was also identified. These are novel genes for S. uberis, which suggests interspecies lateral gene transfer. The presence of resistance genes across the two geographic regions tested within one country supports the need for a careful, tailored, implementation and monitoring of antimicrobial stewardship.
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