SynthesisScientific reports2021
Systematic review and meta-analysis of the efficacy of prophylactic abdominal drainage in major liver resections.
Synthesis in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The E-AHPBA-ESSO-Innsbruck consensus recommendations on peri- and postoperative management following liver resection.The British journal of surgery · 2025Guideline
- Prophylactic drainage versus non-drainage following gastric cancer surgery: a meta-analysis of randomized controlled trials and observational studies.World journal of surgical oncology · 2023Pooled it
- Early drain removal after live liver donor hepatectomy is safe - a randomized controlled pilot study.Langenbeck's archives of surgery · 2023Trial
- Patient blood management and surgery: Impact of new surgical techniques on transfusion needs.Vox sanguinis · 2026Review
- [Management of postoperative bile leaks].Chirurgie (Heidelberg, Germany) · 2026Review
- Outcomes and Cost of Major Liver Resection Using Combined LigaSure and Stapler: A Propensity Score Matching Study.Journal of clinical medicine · 2025Article
- COMPLICATIONS AFTER HEPATECTOMY.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2025Review
- Outcome of the novel description of arterial position changes after major liver resections: retrospective study.BJS open · 2024Article
- Prophylactic Intra-abdominal Drains in Major Elective Surgeries: A Comprehensive Review.Cureus · 2024Review
- Digestive cancer surgery in low-mid income countries: analysis of postoperative mortality and complications in a single-center study.Langenbeck's archives of surgery · 2023Article
- Risk factors and management of biliary leakage after Endocystectomy for hepatic cystic echinococcosis.PLoS neglected tropical diseases · 2023Article
- Neuraxial anesthesia in hepato-pancreatic-bilio surgery: a first western pilot study of 46 patients.Updates in surgery · 2023Article
- A critical appraisal of the ISGLS definition of biliary leakage after liver resection.Langenbeck's archives of surgery · 2023Article
- Liver drains after surgery: what is the real practice? An international snapshot from the Li.DR.A.S. survey.Updates in surgery · 2022Article
- Prospective Study to Evaluate the Safety and Efficacy of a New Surgical Tube Fixation Method: A Pilot Study.World journal of surgery · 2022Article
- Prophylactic drains in totally laparoscopic distal gastrectomy: are they always necessary?World journal of gastroenterology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prophylactic drainage after major liver resection remains controversial. This systematic review and meta-analysis evaluate the value of prophylactic drainage after major liver resection. PubMed, Web of Science, and Cochrane Central were searched. Postoperative bile leak, bleeding, interventional drainage, wound infection, total complications, and length of hospital stay were the outcomes of interest. Dichotomous outcomes were presented as odds ratios (OR) and for continuous outcomes, weighted mean differences (MDs) were computed by the inverse variance method. Summary effect measures are presented together with their corresponding 95% confidence intervals (CI). The certainty of evidence was evaluated using the Grades of Research, Assessment, Development and Evaluation (GRADE) approach, which was mostly moderate for evaluated outcomes. Three randomized controlled trials and five non-randomized trials including 5,050 patients were included. Bile leakage rate was higher in the drain group (OR: 2.32; 95% CI 1.18-4.55; p = 0.01) and interventional drains were inserted more frequently in this group (OR: 1.53; 95% CI 1.11-2.10; p = 0.009). Total complications were higher (OR: 1.71; 95% CI 1.45-2.03; p < 0.001) and length of hospital stay was longer (MD: 1.01 days; 95% CI 0.47-1.56 days; p < 0.001) in the drain group. The use of prophylactic drainage showed no beneficial effects after major liver resection; however, the definitions and classifications used to report on postoperative complications and surgical complexity are heterogeneous among the published studies. Further well-designed RCTs with large sample sizes are required to conclusively determine the effects of drainage after major liver resection.
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