ArticleScientific reports2021
Pupillometry as a reliable metric of auditory detection and discrimination across diverse stimulus paradigms in animal models.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Experience and behavior modulate piriform cortex odor representation in freely moving mice.iScience · 2026Article
- Location-specific neural facilitation in marmoset auditory cortex.Nature communications · 2025Article
- Challenges in using pupil dilation responses to sounds as a reliable alternative to standard audiometric tests.Heliyon · 2025Article
- Perceptual constancy for an odor is acquired through changes in primary sensory neurons.Science advances · 2024Article
- In search of animal normativity: a framework for studying social norms in non-human animals.Biological reviews of the Cambridge Philosophical Society · 2024Article
- Sound elicits stereotyped facial movements that provide a sensitive index of hearing abilities in mice.Current biology : CB · 2024Article
- Article
- Cortical Zinc Signaling Is Necessary for Changes in Mouse Pupil Diameter That Are Evoked by Background Sounds with Different Contrasts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Pupillometry to Assess Auditory Sensation in Guinea Pigs.Journal of visualized experiments : JoVE · 2023Article
- Vocalization categorization behavior explained by a feature-based auditory categorization model.eLife · 2022Article
- Comparison of Pupil Dilation Responses to Unexpected Sounds in Monkeys and Humans.Frontiers in psychology · 2021Article
- Article
- Let's See If You Can Hear: The Effect of Stimulus Type and Intensity to Pupil Diameter Response in Infants and Adults.Ear and hearingArticle
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Estimates of detection and discrimination thresholds are often used to explore broad perceptual similarities between human subjects and animal models. Pupillometry shows great promise as a non-invasive, easily-deployable method of comparing human and animal thresholds. Using pupillometry, previous studies in animal models have obtained threshold estimates to simple stimuli such as pure tones, but have not explored whether similar pupil responses can be evoked by complex stimuli, what other stimulus contingencies might affect stimulus-evoked pupil responses, and if pupil responses can be modulated by experience or short-term training. In this study, we used an auditory oddball paradigm to estimate detection and discrimination thresholds across a wide range of stimuli in guinea pigs. We demonstrate that pupillometry yields reliable detection and discrimination thresholds across a range of simple (tones) and complex (conspecific vocalizations) stimuli; that pupil responses can be robustly evoked using different stimulus contingencies (low-level acoustic changes, or higher level categorical changes); and that pupil responses are modulated by short-term training. These results lay the foundation for using pupillometry as a reliable method of estimating thresholds in large experimental cohorts, and unveil the full potential of using pupillometry to explore broad similarities between humans and animal models.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.