Evidence map›Paper›PMID 33542265›Full record

ArticleScientific reports2021

Repetitive visual cortex transcranial random noise stimulation in adults with amblyopia.

Richard Donkor, Andrew E Silva, Caroline Teske, Margaret Wallis-Duffy, Aaron P Johnson, Benjamin Thompson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

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  15. [Abnormal spontaneous brain functional activity in adult patients with amblyopia: a resting-state functional magnetic resonance imaging study].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Richard DonkorDepartment of Optometry and Vision Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, N0B 2T0, Canada.
Andrew E SilvaDepartment of Optometry and Vision Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, N0B 2T0, Canada.
Caroline TeskeDepartment of Optometry and Vision Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, N0B 2T0, Canada.
Margaret Wallis-DuffyDepartment of Optometry and Vision Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, N0B 2T0, Canada.
Aaron P JohnsonDepartment of Psychology, Concordia University, Montreal, Canada.
Benjamin ThompsonDepartment of Optometry and Vision Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, N0B 2T0, Canada. ben.thompson@uwaterloo.ca.
University of Waterloo · CAConcordia University · CA

Funding

CIHR 390283
6 · The paper itself

Abstract

We tested the hypothesis that five daily sessions of visual cortex transcranial random noise stimulation would improve contrast sensitivity, crowded and uncrowded visual acuity in adults with amblyopia. Nineteen adults with amblyopia (44.2 ± 14.9 years, 10 female) were randomly allocated to active or sham tRNS of the visual cortex (active, n = 9; sham, n = 10). Sixteen participants completed the study (n = 8 per group). tRNS was delivered for 25 min across five consecutive days. Monocular contrast sensitivity, uncrowded and crowded visual acuity were measured before, during, 5 min and 30 min post stimulation on each day. Active tRNS significantly improved contrast sensitivity and uncrowded visual acuity for both amblyopic and fellow eyes whereas sham stimulation had no effect. An analysis of the day by day effects revealed large within session improvements on day 1 for the active group that waned across subsequent days. No long-lasting (multi-day) improvements were observed for contrast sensitivity, however a long-lasting improvement in amblyopic eye uncrowded visual acuity was observed for the active group. This improvement remained at 28 day follow up. However, between-group differences in baseline uncrowded visual acuity complicate the interpretation of this effect. No effect of tRNS was observed for amblyopic eye crowded visual acuity. In agreement with previous non-invasive brain stimulation studies using different techniques, tRNS induced short-term contrast sensitivity improvements in adult amblyopic eyes, however, repeated sessions of tRNS did not lead to enhanced or long-lasting effects for the majority of outcome measures.

Indexed as

Transcranial Direct Current StimulationTranscranial Magnetic StimulationAdultAmblyopiaContrast SensitivityEyeFemaleHumansMaleVisual AcuityVisual Cortex

Identifiers

PMID33542265
PMCPMC7862667
OpenAlexW3126519305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.