ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
The Functional Relevance of Task-State Functional Connectivity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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Who cites it
93 citing papers in PubMed.
- Neurobiological and behavioral relevance of intrinsic functional connectome constraints on task-evoked neural activation.iScience · 2026Article
- A language network in the individualized functional connectomes of 1199 human brains doing arbitrary tasks.Nature communications · 2026Article
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- Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease.Nature communications · 2026Article
- Task-State fMRI-Derived Whole-Brain Functional Topology-Constrained Spiking Neural Network with an Embedded Auditory Core Circuit for Speech Recognition.Biomimetics (Basel, Switzerland) · 2026Article
- Supervised Domain Adaptation Mitigates Cross-Ethnicity Prediction Error in Neuroimaging-Based Cognitive Prediction.bioRxiv : the preprint server for biology · 2026Article
- Association-sensory spatiotemporal hierarchy and functional gradient-regularised recurrent neural network with implications for schizophrenia.NPJ systems biology and applications · 2026Article
- Hierarchical and non-hierarchical network flows generate complementary representational dynamics in human visual cortex.bioRxiv : the preprint server for biology · 2026Article
- Digital Twin Brain simulation and manipulation of a functional brain network underlying mental illness.bioRxiv : the preprint server for biology · 2026Article
- Hemispheric Network Dynamics During Auditory Language Comprehension and Its Clinical Implications Regarding Resting-State Functional Magnetic Resonance Imaging.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Interactions between sensory-biased and supramodal working memory networks in the human cerebral cortex.Communications biology · 2026Article
- Neural activation is enhanced with operational task ecological validity during complex cognitive tasks.Frontiers in human neuroscience · 2026Article
- Distributed cortical network dynamics of binocular convergent eye movements in humans.Network neuroscience (Cambridge, Mass.) · 2026Article
- Regional activity and interregional functional connectivity uniquely contribute to social cognitive judgments during movie-watching.Network neuroscience (Cambridge, Mass.) · 2026Article
- Inter-individual alignment of multimodal brain networks with anatomical constraints.Network neuroscience (Cambridge, Mass.) · 2026Article
- Wired to Regulate: Brain Connectivity Predicts Emotion Regulation Capacity and Tendency.Human brain mapping · 2025Article
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- Identification and External Validation of a Problem Cannabis Risk Network.Biological psychiatry · 2025Article
- Mechanisms of Long-Term Nonexternally Reinforced Preference Change: Functional Connectivity Changes in a Longitudinal Functional MRI Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
33 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
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Abstract
Resting-state functional connectivity has provided substantial insight into intrinsic brain network organization, yet the functional importance of task-related change from that intrinsic network organization remains unclear. Indeed, such task-related changes are known to be small, suggesting they may have only minimal functional relevance. Alternatively, despite their small amplitude, these task-related changes may be essential for the ability of the human brain to adaptively alter its functionality via rapid changes in inter-regional relationships. We used activity flow mapping-an approach for building empirically derived network models-to quantify the functional importance of task-state functional connectivity (above and beyond resting-state functional connectivity) in shaping cognitive task activations in the (female and male) human brain. We found that task-state functional connectivity could be used to better predict independent fMRI activations across all 24 task conditions and all 360 cortical regions tested. Further, we found that prediction accuracy was strongly driven by individual-specific functional connectivity patterns, while functional connectivity patterns from other tasks (task-general functional connectivity) still improved predictions beyond resting-state functional connectivity. Additionally, since activity flow models simulate how task-evoked activations (which underlie behavior) are generated, these results may provide mechanistic insight into why prior studies found correlations between task-state functional connectivity and individual differences in behavior. These findings suggest that task-related changes to functional connections play an important role in dynamically reshaping brain network organization, shifting the flow of neural activity during task performance.
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