Evidence map›Paper›PMID 33541903›Full record

ArticleAJNR. American journal of neuroradiology2021

The Restless Spinal Cord in Degenerative Cervical Myelopathy.

M Hupp, N Pfender, K Vallotton, J Rosner, S Friedl, C M Zipser, R Sutter, M Klarhöfer, J M Spirig, M Betz and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  8. Review
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  11. Comparison of axial and sagittal spinal cord motion measurements in degenerative cervical myelopathy.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 6 countries.

M HuppFrom the Spinal Cord Injury Center (M.H., N.P., K.V., J.R., S.F., C.M.Z., M.S., P.F., A.C.) markus.hupp@balgrist.ch.ORCID 0000-0003-0845-2514
N PfenderFrom the Spinal Cord Injury Center (M.H., N.P., K.V., J.R., S.F., C.M.Z., M.S., P.F., A.C.).ORCID 0000-0003-3933-7463
K VallottonFrom the Spinal Cord Injury Center (M.H., N.P., K.V., J.R., S.F., C.M.Z., M.S., P.F., A.C.).ORCID 0000-0002-3747-730X
J RosnerFrom the Spinal Cord Injury Center (M.H., N.P., K.V., J.R., S.F., C.M.Z., M.S., P.F., A.C.).ORCID 0000-0002-1973-1773
S FriedlFrom the Spinal Cord Injury Center (M.H., N.P., K.V., J.R., S.F., C.M.Z., M.S., P.F., A.C.).ORCID 0000-0001-8686-8537
C M ZipserFrom the Spinal Cord Injury Center (M.H., N.P., K.V., J.R., S.F., C.M.Z., M.S., P.F., A.C.).ORCID 0000-0002-4396-4796
R SutterDepartment of Radiology (R.S.).ORCID 0000-0001-6355-9838
M KlarhöferSiemens Healthcare AG (M.K.), Zurich, Switzerland.ORCID 0000-0002-8975-6546
J M SpirigUniversity Spine Center Zurich (J.M.S., M.B., M.F., A.C.), Balgrist University Hospital, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-5470-284X
M BetzUniversity Spine Center Zurich (J.M.S., M.B., M.F., A.C.), Balgrist University Hospital, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-0214-4003
M SchubertFrom the Spinal Cord Injury Center (M.H., N.P., K.V., J.R., S.F., C.M.Z., M.S., P.F., A.C.).ORCID 0000-0003-4495-6533
P FreundFrom the Spinal Cord Injury Center (M.H., N.P., K.V., J.R., S.F., C.M.Z., M.S., P.F., A.C.).ORCID 0000-0002-4851-2246
M FarshadUniversity Spine Center Zurich (J.M.S., M.B., M.F., A.C.), Balgrist University Hospital, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-7190-1127
A CurtFrom the Spinal Cord Injury Center (M.H., N.P., K.V., J.R., S.F., C.M.Z., M.S., P.F., A.C.).ORCID 0000-0003-0136-8467
Spinal Cord Injury BC · CAUniversity of Zurich · CHMarks and Spencer (United Kingdom) · GBResearch Institute of Radiology · BYSiemens Healthcare (United States) · USUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe spinal cord is subject to a periodic, cardiac-related movement, which is increased at the level of a cervical stenosis. Increased oscillations may exert mechanical stress on spinal cord tissue causing intramedullary damage. Motion analysis thus holds promise as a biomarker related to disease progression in degenerative cervical myelopathy. Our aim was characterization of the cervical spinal cord motion in patients with degenerative cervical myelopathy. MATERIALS AND

methodsPhase-contrast MR imaging data were analyzed in 55 patients (37 men; mean age, 56.2 [SD,12.0] years; 36 multisegmental stenoses) and 18 controls (9 men,

resultsIn patients, mean craniocaudal oscillations were increased manifold at any level of a cervical stenosis (eg, C5 displacement: controls [

conclusionsPatients with degenerative cervical myelopathy show altered spinal cord motion with increased and ongoing oscillations at and also beyond the focal level of stenosis. Phase-contrast MR imaging has promise as a biomarker to reveal mechanical stress to the cord and may be applicable to predict disease progression and the impact of surgical interventions.

Indexed as

AdultAgedCervical CordDisease ProgressionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMotionSpinal Cord DiseasesSpinal Stenosis

Identifiers

PMID33541903
PMCPMC7959437
OpenAlexW3126661475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.