ArticleSeminars in perinatology2021
Preterm birth lifetime costs in the United States in 2016: An update.
Article in Seminars in perinatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 8 syntheses or guidelines pooled it, 177 citations in OpenAlex.
- Birth outcomes for women with pre-existing mental health problems: a systematic review and meta-analysis.BMJ open · 2026Pooled it
- Early gestational prediction of spontaneous preterm birth using a validated three-protein serum biomarker panel.BMC medicine · 2026Pooled it
- Global inequities in the survival of extremely preterm infants: a systematic review and meta-analysis.BMC pediatrics · 2025Pooled it
- Economic evaluations of human milk for very preterm infants: a systematic review.Frontiers in pediatrics · 2025Pooled it
- Environmental Exposure to Per- and Polyfluorylalkyl Substances (PFASs) and Reproductive Outcomes in the General Population: A Systematic Review of Epidemiological Studies.International journal of environmental research and public health · 2024Pooled it
- The Annual Economic Burden of Uterine Fibroids in the United States (2010 Versus 2022): A Comparative Cost-Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2024Pooled it
- Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in twin gestations: a systematic review and meta-analysis.American journal of obstetrics and gynecology · 2023Pooled it
- Sexual Violence During Armed Conflict Among Women and Girls in Ethiopia: A Systematic Review and Meta-Analysis.Journal of the International Association of Providers of AIDS CarePooled it
- Cost-effectiveness of a randomized controlled trial comparing low-dose aspirin to placebo for the prevention of recurrent preterm birth.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Trial
- A decomposition analysis to evaluate the role of social, chemical, and neighborhood factors on the Black/White disparity in preterm birth in Greater Houston, Texas.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Inhaled vitamin A mitigates hyperoxia-induced acute and chronic lung damage in a neonatal rat model of bronchopulmonary dysplasia.American journal of respiratory cell and molecular biology · 2026Article
- Very Preterm Infant Retinal Microanatomy at 36 Weeks' Postmenstrual Age and 2-Year Neurodevelopment.JAMA ophthalmology · 2026Article
- A reduction in large animal research threatens the perinatal translation research pipeline.Pediatric research · 2026Review
- "Actionable" risk for preterm birth: patterns and prediction in California singleton births 2016-2020.BMC pregnancy and childbirth · 2026Article
- Trends in admissions and costs for neonatal intensive care in US children's hospitals, 2017-2022.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Individual and Community-Level Predictors of Anemia in Chicago-Area Pregnancies: A Multi-Level Analysis of Electronic Health Record Data.Birth (Berkeley, Calif.) · 2026Article
- Duration of virtual maternity program engagement and neonatal outcomes: A multistate retrospective cohort study.Pregnancy (Hoboken, N.J.) · 2026Article
- Estimating Baseline Cutoffs for DHA Dosage in Preterm Birth Prevention: A Bayesian Personalized Change-Point Analysis.Journal of applied statistics · 2026Article
- Neonatal impact of maternal biomarker screening for risk of preterm birth with targeted interventions (PRIME): A multicenter, randomized, controlled trial.Pregnancy (Hoboken, N.J.) · 2026Article
- Therapeutic effect and mechanism of different doses of aspirin on preterm delivery in pregnant mice.PloS one · 2026Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The societal cost of preterm birth indicates potential economic gains from interventions that reduce the incidence of preterm birth. Changes in the epidemiology of preterm birth and healthcare costs require periodic updates to cost estimates. Previously reported incremental cost estimates for the United States in 2004 were updated. The discounted present value of the excess cost associated with prematurity for the 2016 US birth cohort was estimated to be $25.2 billion: $17.1 billion for medical care of persons born preterm, $2.0 billion for delivery care, $1.3 billion for early intervention and special education, and $4.8 billion in lost productivity due to associated disabilities in adults. The nominal and inflation-adjusted incremental costs per preterm birth increased by 26% and 4%, respectively, during 2004-2016. The aggregate cost decreased by 4%, associated with declines in overall births and the preterm birth rate and changes in the distribution by gestational age.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.