ArticleFluids and barriers of the CNS2021
The relationship between cerebral blood flow and venous sinus pressure: can hyperemia induce idiopathic intracranial hypertension?
Article in Fluids and barriers of the CNS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 41 citations in OpenAlex.
- Trans-stenotic pressure gradient in symptomatic transverse sinus stenosis: clinical, laboratory, and imaging correlates.Quantitative imaging in medicine and surgery · 2026Article
- Reduced cerebral blood flow does not alter concurrent or post-intervention inhibitory control: evidence from a 3-h head-down tilt protocol in healthy young adults.Experimental brain research · 2026Article
- Personalized Computational Fluid Dynamics Analysis of Cerebral Venous Hemodynamics in a Case of Deep Cerebral Vein Thrombosis.Journal of personalized medicine · 2025Article
- Shear Stress Targeted Delivery of Nitroglycerin to Brain Collaterals Improves Ischaemic Stroke Outcome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Brain Ischemia in Alzheimer's Disease May Partly Counteract the Disruption of the Blood-Brain Barrier.Brain sciences · 2025Article
- Phase-contrast MRI analysis of cerebral blood and CSF flow dynamic interactions.Fluids and barriers of the CNS · 2024Article
- Regulation of brain fluid volumes and pressures: basic principles, intracranial hypertension, ventriculomegaly and hydrocephalus.Fluids and barriers of the CNS · 2024Review
- A new method for assessing transverse sinus stenosis with CT venography based on the venous trans-stenotic pressure gradient.Journal of neurointerventional surgery · 2023Article
- A scoping review of the discrepancies in the measurement of cerebral blood flow in idiopathic intracranial hypertension: oligemia, euvolemia or hyperemia?Fluids and barriers of the CNS · 2023Article
- Dynamics of cerebrospinal fluid pressure alterations and bilateral transverse-sigmoid sinus morphologies in Asian patients with venous pulsatile tinnitus.The Journal of international medical research · 2023Article
- Estimation of venous sinus pressure drop in patients with idiopathic intracranial hypertension using 4D-flow MRI.European radiology · 2023Article
- Gravitational effects on carotid and jugular characteristics in graded head-up and head-down tilt.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Dilatation of the bridging cerebral cortical veins in childhood hydrocephalus suggests a malfunction of venous impedance pumping.Scientific reports · 2022Article
- A perspective on spaceflight associated neuro-ocular syndrome causation secondary to elevated venous sinus pressure.NPJ microgravity · 2022Review
- Integrated understanding of hydrocephalus - a practical approach for a complex disease.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been shown that idiopathic intracranial hypertension (IIH) in children is associated with cerebral hyperemia, which induces an increase in cerebral venous pressure. The current literature suggests venous pressure scales with blood flow in a linear fashion, however, a linear relationship would not raise the pressure high enough to induce IIH. There is, however, some evidence to suggest that this relationship could be quadratic in nature. The purpose of this paper is to characterize the relationship between cerebral blood flow and the pressure drop across the cerebral venous system.
methods10 CT venogram data sets were collected for this study, with 5 useable geometries created. Computational fluid dynamics (CFD) models were generated using these geometries, with 10 simulations conducted per patient. The flow rates tested ranged from 200 mL/min to 2000 mL/min. 3D pressure and velocity streamline distributions were created and analyzed for each CFD model, with pressure drops across the cerebral venous system determined. The effective and hydraulic diameters were determined at the superior sagittal sinus, transverse sinus and both proximal and distal sigmoid sinuses.
resultsA quadratic relationship between blood flow and sinus pressure was found, with correlations of 0.99 or above in all five patients. The presence of vortical blood flow was found to explain this trend, with fluid curl and pressure drop correlations being above 0.97. This suggests that the presence of high blood flow should be considered in the diagnostic workup of IIH.
conclusionsThe cerebral venous sinus blood flow and pressure response relationship are quadratic in nature, with the major cause of this being the degree of rotation induced in the flow. The elevated blood flow found in children with IIH can explain the increased ICP that is found, secondary to the increase in venous pressure that develops.
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