ArticleHealth and quality of life outcomes2021
Responsiveness of PROMIS and Patient Health Questionnaire (PHQ) Depression Scales in three clinical trials.
Article in Health and quality of life outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Care Management for the Effective Use of Opioids (CAMEO)
Stroke Self-Management: Effect on Function and Stroke Quality of Life
Strategies for Prescribing Analgesics Comparative Effectiveness (SPACE) Trial
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Measurement properties and interpretability of the PROMIS item banks in stroke patients: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Pooled it
- Examining the psychometric properties of brief screening measures of depression and anxiety in chronic pain: The Patient Health Questionnaire 2-item and Generalized Anxiety Disorder 2-item.Pain practice : the official journal of World Institute of Pain · 2022Pooled it
- Genotype-Guided Antidepressant Prescribing for Patients With Depression: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Bright IDEAS-YA Skills Training and Psychosocial Outcomes of Young Adults With Cancer: A Randomized Clinical Trial.JAMA network open · 2026Trial
- The impact of levodopa on post-stroke depression: the ESTREL-depression-study.European stroke journal · 2026Trial
- Age Self Care-Resilience, a medical group visit program targeting pre-frailty: A mixed methods pilot clinical trial.The Journal of frailty & aging · 2025Trial
- Change starts with the body: Interoceptive appreciation mediates the effect of mindfulness training on behavior change - an effect moderated by depression severity.Psychiatry research · 2024Trial
- Effectiveness of a Community Health Worker-Delivered Depression Intervention for Uninsured Latine Immigrants.Journal of community health · 2026Article
- Association of Air Pollution and Socioeconomic Deprivation with Depression and Pain.International journal of environmental research and public health · 2026Article
- Low depression rates among caregivers of young children with sickle cell disease: a rapid report.Journal of sickle cell disease · 2026Article
- Music-evoked EEG signals for mental health assessment using two- and three-class classification.Frontiers in systems neuroscience · 2026Article
- Digital health tools and point solutions-pitfalls in population health program measurement.Frontiers in digital health · 2026Article
- Observational
- Sleep quality and lymphedema in breast cancer survivors: a mixed method analysis.Journal of cancer survivorship : research and practice · 2025Article
- A pilot intervention to reduce burnout and enhance resilience through transcendental meditation among Georgetown University medical students.BMC medical education · 2025Article
- The NIH HEAL pain common data elements (CDE): a great start but a long way to the finish line.Pain medicine (Malden, Mass.) · 2025Review
- Minimally important difference and responsiveness to change for numerical rating scale of menstrual pain severity: a psychometric study.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Quantitative Assessment of Psychological Stress Changes Before and After Ureteral Stent Placement: A Prospective Observational Study.Patient preference and adherence · 2025Article
- Feasibility and acceptability of a single-session perioperative acceptance and commitment therapy workshop for preventing chronic postsurgical pain: a single-arm, non-randomized pilot trial.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Is the PHQ-2 a Good Measure to Inform Providers About Patient Well-Being and Functioning? Data From the Veterans Health and Life Survey.Medical care · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundThe PROMIS depression scales are reliable and valid measures that have extensive normative data in general population samples. However, less is known about how responsive they are to detect change in clinical settings and how their responsiveness compares to legacy measures. The purpose of this study was to assess and compare the responsiveness of the PROMIS and Patient Health Questionnaire (PHQ) depression scales in three separate samples.
methodsWe used data from three clinical trials (two in patients with chronic pain and one in stroke survivors) totaling 651 participants. At both baseline and follow-up, participants completed four PROMIS depression fixed-length scales as well as legacy measures: Patient Health Questionnaire 9-item and 2-item scales (PHQ-9 and PHQ-2) and the SF-36 Mental Health scale. We measured global ratings of depression change, both prospectively and retrospectively, as anchors to classify patients as improved, unchanged, or worsened. Responsiveness was assessed with standardized response means, statistical tests comparing change groups, and area-under-curve analysis.
resultsThe PROMIS depression and legacy scales had generally comparable responsiveness. Moreover, the four PROMIS depression scales of varying lengths were similarly responsive. In general, measures performed better in detecting depression improvement than depression worsening. For all measures, responsiveness varied based on the study sample and on whether depression improved or worsened.
conclusionsBoth PROMIS and PHQ depression scales are brief public domain measures that are responsive (i.e., sensitive to change) and thus appropriate as outcome measures in research as well as for monitoring treatment in clinical practice. Trial registration ClinicalTrials.gov ID: NCT01236521, NCT01583985, NCT01507688.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.