Evidence map›Paper›PMID 33541298›Full record

ArticleBMC ophthalmology2021

Predicting visual acuity in Bietti crystalline dystrophy: evaluation of image parameters.

Chu-Yen Huang, Eugene Yu-Chuan Kang, Lung-Kun Yeh, An-Lun Wu, Pei-Kang Liu, I-Wen Huang, Joseph Ryu, Laura Liu, Wei-Chi Wu, Chi-Chun Lai and 2 more

Open access · goldAbstract read
In one paragraph

Article in BMC ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Relationship between outer retinal tubulation, retinal volume, and visual field in Bietti crystalline dystrophy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Chu-Yen HuangDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Eugene Yu-Chuan KangDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Lung-Kun YehDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
An-Lun WuDepartment of Ophthalmology, Mackay Memorial Hospital, Hsinchu, Taiwan.
Pei-Kang LiuDepartment of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, Columbia University, New York, USA.
I-Wen HuangDepartment of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, Columbia University, New York, USA.
Joseph RyuDepartment of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, Columbia University, New York, USA.
Laura LiuDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Wei-Chi WuDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Chi-Chun LaiDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Kuan-Jen ChenDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan. cgr999chiayi@yahoo.com.tw.
Nan-Kai WangDepartment of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, Columbia University, New York, USA. wang.nankai@gmail.com.ORCID http://orcid.org/0000-0002-6277-9879
Chang Gung University · TWColumbia University · USChang Gung University of Science and Technology · TWColumbia University Irving Medical Center · USMackay Memorial Hospital · TWNational Sun Yat-sen University · TW

Funding

Reprogramming the metabolome to overcome the genetic heterogeneity in retinitis pigmentosaR01EY031354 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WANG, NAN-KAI · 2020 to 2024
$2.0M
Chang Gung Memorial Hospital, Linkou CMRPG3F1243Chang Gung Memorial Hospital, Linkou CMRPG3K1681Ministry of Science and Technology, Taiwan MOST 106-2314-B-182A-041NEI NIH HHS NEI R01EY031354NEI NIH HHS R01 EY031354
6 · The paper itself

Abstract

backgroundTo analyze multiple imaging modalities in patients with Bietti crystalline dystrophy (BCD) and to investigate which factors from these modalities are associated with best corrected visual acuity (BCVA).

methodsIn this retrospective study, 40 eyes from 22 patients with BCD were included and were separated into group 1 (BCVA ≤20/200) and group 2 (BCVA > 20/200). Data including BCVA and characteristic findings from near-infrared reflectance (NIR) imaging, fundus autofluorescence (FAF), and spectral domain-optic coherence tomography (SD-OCT) were analyzed and compared. The outcome measures of multimodal imaging were evaluated for correlation with BCVA.

resultsNIR is a good diagnostic tool for detecting either crystalline or sclerotic vessels in BCD. Patients in group 1 tended to have a thinner choroid (P = 0.047) with ellipsoid zone (EZ) disruption (P = 0.011). Calculation of the area under the curve indicated that EZ disruption detected on SD-OCT could be a good predictor of legal blindness in BCD.

conclusionFor the diagnosis of BCD, NIR could be a good diagnostic tool. Of the studied imaging modalities, we found that EZ disruption at the fovea were strongly associated with legal blindness, which could be easily assessed by SD-OCT.

Indexed as

Tomography, Optical CoherenceCorneal Dystrophies, HereditaryFluorescein AngiographyHumansRetinal DiseasesRetrospective StudiesVisual AcuityBest corrected visual acuity (BCVA)Bietti crystalline dystrophy (BCD)Choroidal thicknessCrystallineEllipsoid zone disruptionFundus autofluorescence (FAF)Near-infrared reflectance (NIR)Sclerotic vesselsSpectral domain-optical coherence tomography (SD-OCT)

Identifiers

PMID33541298
PMCPMC7860191
OpenAlexW3126587831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.