Evidence map›Paper›PMID 33541227›Full record

ArticlePublic health reports (Washington, D.C. : 1974)

Sensitivity and Specificity of the National Death Index for Multiple Causes of Death in People With HIV.

Sandra Schwarcz, Nancy A Hessol, Matthew A Spinelli, Ling Chin Hsu, Daniel Wlodarczyk, Jacqueline Tulsky, Meg D Newman, Susan P Buchbinder

Abstract read
In one paragraph

Article in Public health reports (Washington, D.C. : 1974). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sandra Schwarcz7152 San Francisco Department of Public Health, San Francisco, CA, USA.ORCID 0000-0001-7611-4387
Nancy A Hessol8785 Department of Clinical Pharmacy and Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-3374-8384
Matthew A SpinelliDivision of HIV, ID, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
Ling Chin Hsu7152 San Francisco Department of Public Health, San Francisco, CA, USA.ORCID 0000-0002-4894-3492
Daniel WlodarczykDivision of HIV, ID, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
Jacqueline TulskyDivision of HIV, ID, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
Meg D NewmanDivision of HIV, ID, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
Susan P Buchbinder7152 San Francisco Department of Public Health, San Francisco, CA, USA.

Funding

San Francisco Vaccine and Prevention UnitUM1AI069496 · NIAID · PUBLIC HEALTH FOUNDATION ENTERPRISES · PI Susan Buchbinder, Diane V Havlir · 2012 to 2026
$30.5M
CBA (HIV) PREVENTION SERVICES FOR RACIAL/ETHNIC MINORITY POPULATIONSU65PS924536 · PS · AIDS PROJECT LOS ANGELES, INC. · PI AYALA, GEORGE · 2004 to 2009
$2.4M
NCHHSTP CDC HHS NU62PS924536NCHHSTP CDC HHS U65 PS924536NIAID NIH HHS UM1 AI069496
6 · The paper itself

Abstract

objectivesInaccuracies in cause-of-death information in death certificates can reduce the validity of national death statistics and result in poor targeting of resources to reduce morbidity and mortality in people with HIV. Our objective was to measure the sensitivity, specificity, and agreement between multiple causes of deaths from death certificates obtained from the National Death Index (NDI) and causes determined by expert physician review.

methodsPhysician specialists determined the cause of death using information collected from the medical records of 50 randomly selected HIV-infected people who died in San Francisco from July 1, 2016, through May 31, 2017. Using expert review as the gold standard, we measured sensitivity, specificity, and agreement.

resultsThe NDI had a sensitivity of 53.9% and a specificity of 66.7% for HIV deaths. The NDI had a moderate sensitivity for non-AIDS-related infectious diseases and non-AIDS-related cancers (70.6% and 75.0%, respectively) and high specificity for these causes (100.0% and 94.7%, respectively). The NDI had low sensitivity and high specificity for substance abuse (27.3% and 100.0%, respectively), heart disease (58.3% and 86.8%, respectively), hepatitis B/C (33.3% and 97.7%, respectively), and mental illness (50.0% and 97.8%, respectively). The measure of agreement between expert review and the NDI was lowest for HIV (κ = 0.20); moderate for heart disease (κ = 0.45) and hepatitis B/C (κ = 0.40); high for non-AIDS-related infectious diseases (κ = 0.76) and non-AIDS-related cancers (κ = 0.72); and low for all other causes of death (κ < 0.35).

conclusionsOur findings support education and training of health care providers to improve the accuracy of cause-of-death information on death certificates.

Indexed as

Death CertificatesAdultAgedCause of DeathComorbidityData CollectionFemaleHIV InfectionsHumansMaleMiddle AgedSan FranciscoSensitivity and Specificitydeath certificate biasHIVmortality statisticssensitivityspecificityvalidation

Identifiers

PMID33541227
PMCPMC8361560

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.