Evidence map›Paper›PMID 33541041›Full record

SynthesisEuropean journal of physical and rehabilitation medicine2021

Comorbidity in traumatic brain injury and functional outcomes: a systematic review.

Sara Hanafy, Chen Xiong, Vincy Chan, Mitchell Sutton, Michael Escobar, Angela Colantonio, Tatyana Mollayeva

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of physical and rehabilitation medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  15. Which risk factors significantly influence the outcome of traumatic brain injured patients with alcohol use disorder?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sara HanafyFaculty of Medicine, Rehabilitation Sciences Institute, University of Toronto, Toronto, ON, Canada - sara.hanafy@mail.utoronto.ca.
Chen XiongFaculty of Medicine, Rehabilitation Sciences Institute, University of Toronto, Toronto, ON, Canada.
Vincy ChanFaculty of Medicine, Rehabilitation Sciences Institute, University of Toronto, Toronto, ON, Canada.
Mitchell SuttonKITE-Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada.
Michael EscobarDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Angela ColantonioFaculty of Medicine, Rehabilitation Sciences Institute, University of Toronto, Toronto, ON, Canada.
Tatyana MollayevaFaculty of Medicine, Rehabilitation Sciences Institute, University of Toronto, Toronto, ON, Canada.

Funding

Machine learning to inform health services and policy for traumatic brain injuryR01NS117921 · NINDS · UNIVERSITY OF TORONTO · PI COLANTONIO, ANGELA, ESCOBAR, MICHAEL D · 2020 to 2021
$374k
Comorbidity in traumatic brain injury and risk of all-cause mortality, functional and financial burden: a decade-long population based cohort studyR21HD089106 · NICHD · UNIVERSITY HEALTH NETWORK · PI COLANTONIO, ANGELA · 2016 to 2017
$297k
NICHD NIH HHS R21 HD089106NINDS NIH HHS R01 NS117921
6 · The paper itself

Abstract

introductionComorbidities in people with traumatic brain injury (TBI) may negatively impact injury recovery course and result in long-term disability. Despite the high prevalence of several categories of comorbidities in TBI, little is known about their association with patients' functional outcomes. We aimed to systematically review the current evidence to identify comorbidities that affect functional outcomes in adults with TBI. EVIDENCE ACQUISITION: A systematic search of Medline, Cochrane Central Register of Controlled Trials, Embase and PsycINFO was conducted from 1997 to 2020 for prospective and retrospective longitudinal studies published in English. Three researchers independently screened and assessed articles for fulfillment of the inclusion criteria. Quality assessment followed the Quality in Prognosis Studies tool and the Scottish Intercollegiate Guidelines Network methodology recommendations. EVIDENCE SYNTHESIS: Twenty-two studies of moderate quality discussed effects of comorbidities on functional outcomes of patients with TBI. Cognitive and physical functioning were negatively affected by comorbidities, although the strength of association, even within the same categories of comorbidity and functional outcome, differed from study to study. Severity of TBI, sex/gender, and age were important factors in the relationship. Due to methodological heterogeneity between studies, meta-analyses were not performed.

conclusionsEmerging evidence highlights the adverse effect of comorbidities on functional outcome in patients with TBI, so clinical attention to this topic is timely. Future research on the topic should emphasize time of comorbidity onset in relation to the TBI event, to support prevention, treatment, and rehabilitation. PROSPERO registration (CRD 42017070033).

Indexed as

ComorbidityDisability EvaluationOutcome Assessment, Health CareBrain Injuries, TraumaticHumansPrognosis

Identifiers

PMID33541041
PMCPMC10396401

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.