Evidence map›Paper›PMID 33541020›Full record

ArticleZhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology2021

[Research progress in gene therapy for Wilson's disease].

S Tang, L Bai, S J Zheng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. [Research progresses in gene therapy for hepatolenticular degeneration].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

S TangThe First Unit, Department of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China.
L BaiThe Fourth Unit, Department of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Beijing 100069, China.
S J ZhengThe First Unit, Department of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China.
Beijing YouAn Hospital · CN

Funding

Science and Technology Innovation Service Capacity Building-highprecision Discipline Construction Project 11920703The Digestive Medical Coordinated Development Center of Beijing Municipal Administration of Hospitals XXZ0503
6 · The paper itself

Abstract

Wilson's disease (WD) is a kind of inherited single-gene autosomal recessive disorder in which mutations in the ATP7B gene cause copper excretion disorders. Drug therapy is currently the main treatment method for WD. Liver transplantation should be considered for poor drug response or acute liver failure. However, it faces problems such as medication adherence, adverse reactions and shortage of liver source. Gene therapy in WD may permanently correct abnormal copper metabolism, which is why it is the focus of current research. This article summarizes the research progress of WD around gene therapy vectors and CRISPR/Cas9 gene editing system.

Indexed as

Hepatolenticular DegenerationCopperCopper-Transporting ATPasesGenetic TherapyHumansMutationCopperCopper-Transporting ATPasesATP7BGene therapyWilson disease

Identifiers

PMID33541020
PMCPMC12813836
OpenAlexW3126460055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.