Evidence map›Paper›PMID 33540895›Full record

ReviewInternational journal of molecular sciences2021

Silk Fibroin as a Functional Biomaterial for Tissue Engineering.

Weizhen Sun, David Alexander Gregory, Mhd Anas Tomeh, Xiubo Zhao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 195 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
195citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

195 citing papers in PubMed, 1 synthesis or guideline pooled it.

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135 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Weizhen SunDepartment of Chemical and Biological Engineering, University of Sheffield, Sheffield S1 3JD, UK.
David Alexander GregoryDepartment of Chemical and Biological Engineering, University of Sheffield, Sheffield S1 3JD, UK.ORCID 0000-0003-2489-5462
Mhd Anas TomehDepartment of Chemical and Biological Engineering, University of Sheffield, Sheffield S1 3JD, UK.
Xiubo ZhaoDepartment of Chemical and Biological Engineering, University of Sheffield, Sheffield S1 3JD, UK.ORCID 0000-0002-4620-2893

Funding

Engineering and Physical Sciences Research Council EP/N007174/1 and EP/N023579/1Jangsu province, department of education Jiangsu specially appointed professor programThe Royal Society RG160662
6 · The paper itself

Abstract

Tissue engineering (TE) is the approach to combine cells with scaffold materials and appropriate growth factors to regenerate or replace damaged or degenerated tissue or organs. The scaffold material as a template for tissue formation plays the most important role in TE. Among scaffold materials, silk fibroin (SF), a natural protein with outstanding mechanical properties, biodegradability, biocompatibility, and bioresorbability has attracted significant attention for TE applications. SF is commonly dissolved into an aqueous solution and can be easily reconstructed into different material formats, including films, mats, hydrogels, and sponges via various fabrication techniques. These include spin coating, electrospinning, freeze drying, physical, and chemical crosslinking techniques. Furthermore, to facilitate fabrication of more complex SF-based scaffolds with high precision techniques including micro-patterning and bio-printing have recently been explored. This review introduces the physicochemical and mechanical properties of SF and looks into a range of SF-based scaffolds that have been recently developed. The typical TE applications of SF-based scaffolds including bone, cartilage, ligament, tendon, skin, wound healing, and tympanic membrane, will be highlighted and discussed, followed by future prospects and challenges needing to be addressed.

Indexed as

Absorbable ImplantsAnimalsBiocompatible MaterialsBiopolymersBioprintingExtracellular MatrixFibroinsHumansHydrogelsInsectaMaterials TestingMechanical PhenomenaOrgan SpecificityProtein ConformationRegenerationSpecies SpecificityBiocompatible MaterialsBiopolymersFibroinsHydrogelsbiomaterialscaffoldsilk fibrointissue engineering

Identifiers

PMID33540895
PMCPMC7867316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.