Evidence map›Paper›PMID 33540559›Full record

ArticleInternational journal of molecular sciences2021

Peripheral Blood miRome Identified miR-155 as Potential Biomarker of MetS and Cardiometabolic Risk in Obese Patients.

Alvaro Cerda, Adonai Aralim Amaral, Raquel de Oliveira, Tamiris Invencioni Moraes, Aécio Assunção Braga, Magda Elizabeth Graciano-Saldarriaga, Cristina Moreno Fajardo, Thiago Dominguez Crespo Hirata, Vivian Bonezi, Antony Brayan Campos-Salazar and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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  14. The Functional Mechanism of MicroRNA in Oral Lichen Planus.Journal of inflammation research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Alvaro CerdaCenter of Excellence in Translational Medicine, CEMT-BIOREN & Department of Basic Sciences, Universidad de La Frontera, Av. Alemania 0458, Temuco 4810296, Chile.ORCID 0000-0003-3428-8332
Adonai Aralim AmaralDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
Raquel de OliveiraDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
Tamiris Invencioni MoraesDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
Aécio Assunção BragaDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
Magda Elizabeth Graciano-SaldarriagaDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
Cristina Moreno FajardoDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
Thiago Dominguez Crespo HirataDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.ORCID 0000-0002-3967-8121
Vivian BoneziDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
Antony Brayan Campos-SalazarDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
Egidio Lima DoreaUniversity Hospital, University of Sao Paulo, Av. Prof. Lineu Prestes 2565, Sao Paulo 05508-000, Brazil.
Marcia Martins Silveira BernikUniversity Hospital, University of Sao Paulo, Av. Prof. Lineu Prestes 2565, Sao Paulo 05508-000, Brazil.
Mario Hiroyuki HirataDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
Rosario Dominguez Crespo HirataDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo 05508-000, Brazil.
Universidade de São Paulo · BRHospital Universitário da Universidade de São Paulo · BRUniversidad de La Frontera · CL

Funding

Comisión Nacional de Investigación Científica y Tecnológica 11150445Comisión Nacional de Investigación Científica y Tecnológica REDI170632Conselho Nacional de Desenvolvimento Científico e Tecnológico 457334/2013-4Conselho Nacional de Desenvolvimento Científico e Tecnológico 462778/2014-2Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Code 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2009/10069-2
6 · The paper itself

Abstract

This study explored circulating miRNAs and target genes associated with metabolic syndrome (MetS) and cardiometabolic risk in obese patients. Small-RNA sequencing was used to assess the peripheral blood miRNome of 12 obese subjects (6 MetS and 6 non-MetS). Differentially expressed miRNAs and target genes were further analyzed by qPCR in a larger sample of obese patients (48 MetS and 32 non-MetS). miRNA:mRNA interactions were studied using in silico tools. miRNome analysis identified 10 downregulated miRNAs in MetS compared to non-Met patients (

Indexed as

Signal TransductionAdiponectinAdultBiomarkersCardiovascular DiseasesCCAAT-Enhancer-Binding Protein-betaComputer SimulationFemaleFibrinogenHumansMaleMetabolic SyndromeMicroRNAsMiddle AgedObesityProto-Oncogene MasAdiponectinBiomarkersCCAAT-Enhancer-Binding Protein-betaCEBPB protein, humanFibrinogenMAS1 protein, humanMicroRNAsMIRN155 microRNA, humanProto-Oncogene MasReceptor, Insulincardiometabolic riskCEBPBmetabolic syndromemicroRNAsmiR-155obesity

Identifiers

PMID33540559
PMCPMC7867145
OpenAlexW3128656663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.