ArticleJournal of clinical medicine2021
Impact of the 25-Hydroxycholecalciferol Concentration and Vitamin D Deficiency Treatment on Changes in the Bone Level at the Implant Site during the Process of Osseointegration: A Prospective, Randomized, Controlled Clinical Trial.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06452251 (Vitamin-D Insufficiency Leads to Interleukin-10 Reduction in Peri-implant Tissues), which is not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vitamin-D Insufficiency Leads to Interleukin-10 Reduction in Peri-implant Tissues: A Case-Control Study
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Impact of Vitamin D on Osseointegration in Dental Implants: A Systematic Review of Human Studies.Nutrients · 2024Pooled it
- Influence of Serum Vitamin D Levels on Survival Rate and Marginal Bone Loss in Dental Implants: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Does vitamin D have an effect on osseointegration of dental implants? A systematic review.International journal of implant dentistry · 2022Pooled it
- Association Between Serum 25-Hydroxyvitamin D Status and Long-Term Marginal Bone Loss Around Dental Implants.Journal of clinical medicine · 2026Article
- The effect of dietary factors and nutrients on osseointegration, dental implant success and survival: a scoping review.International journal of implant dentistry · 2026Article
- Vitamin D deficiency and disease conditions relevant to: Orthopaedic translation.Journal of orthopaedic translation · 2026Review
- The Prevalence of Early Implant Failure and Associated Risk Factors: A Retrospective Study.Journal of clinical and experimental dentistry · 2026Review
- Vitamin D-Loaded Chitosan Nanostructures for Bone Regeneration: A Combined In Vitro and In Vivo Evaluation in an Osteoporotic Rat Model.Medicina (Kaunas, Lithuania) · 2025Article
- Does vitamin D levels influence the incidence of peri-implantitis? A systematic review of current evidence.The Saudi dental journal · 2025Review
- Vitamin - D supplements for better osteointegration in dental implant surgery: A randomized control trial.Bioinformation · 2025Article
- Post-operative supplementation with vitamin D after mucogingival surgery significantly enhances autophagy and improves life quality following feline chronic gingivostomatitis.International journal of veterinary science and medicine · 2025Article
- Resonance frequency analysis of dental implants in patients with vitamin D deficiency.Clinical oral investigations · 2024Article
- Can Vitamin D Levels Influence Bone Metabolism and Osseointegration of Dental Implants? An Umbrella Review.Healthcare (Basel, Switzerland) · 2024Review
- New Radiological Corticalization Index as an Indicator of Implant Success Rate Depending on Prosthetic Restoration-5 Years of Follow-Up.Diagnostics (Basel, Switzerland) · 2024Article
- Is Corticalization in Radiographs Related to a Higher Risk of Bone Loss around Dental Implants in Smoking Patients? A 5-Year Observation of Radiograph Bone-Texture Changes.Journal of clinical medicine · 2023Article
- Vitamin DInternational journal of molecular sciences · 2023Review
- Are Torque-Induced Bone Texture Alterations Related to Early Marginal Jawbone Loss?Journal of clinical medicine · 2022Article
- Effect of Vitamin D on Bone Regeneration: A Review.Medicina (Kaunas, Lithuania) · 2022Review
- Hormone and implant osseointegration: Elaboration of the relationship among function, preclinical, and clinical practice.Frontiers in molecular biosciences · 2022Review
- Vitamin D Enhanced the Osteogenic Differentiation of Cell Spheroids Composed of Bone Marrow Stem Cells.Medicina (Kaunas, Lithuania) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe most important factor which is responsible for the positive course of implant treatment is the process of osseointegration between the implant structure and the host's bone tissue. The aim of this study was to assess what effect the 25-hydroxycholecalciferol concentration and vitamin D deficiency treatment have on changes in the bone level at the implant site during the process of osseointegration in the mandible. MATERIALS AND
methodsThe study was with 122 people qualified for implant surgery, who were assigned to three research groups (A, B, and C). Laboratory, clinical, and radiological tests were performed on the day of surgery, and after 6 and 12 weeks. The bone level in the immediate proximity of the implant was determined by radiovisiography (RVG).
resultsThe bone level after 12 weeks in Groups B and C was significantly higher than after 6 weeks. The bone level in the study Group B was significantly higher than in Group A. The study showed that the higher the levels of 25-hydroxycholecalciferol were observed on the day of surgery, the higher was the level of bone surrounding the implant after 6 and 12 after surgery.
conclusionThe correct level of 25-hydroxycholecalciferol on the day of surgery and vitamin D deficiency treatment significantly increase the bone level at the implant site in the process of radiologically assessed osseointegration.
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Registered trials
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