Evidence map›Paper›PMID 33540223›Full record

Trial reportGeneral hospital psychiatry

The role of social isolation in physical and emotional outcomes among patients with chronic pain.

Sarah Bannon, Jonathan Greenberg, Ryan A Mace, Joseph J Locascio, Ana-Maria Vranceanu

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in General hospital psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Chronic disease and social isolation among Canadians: evidence from the 2022 Mental Health and Access to Care Survey.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Chronic pain in the aging adult with sickle cell disease.Frontiers in pain research (Lausanne, Switzerland) · 2026
    Review
  13. Article
  14. Observational
  15. The Role of Psychologists in Treating Pelvic Pain Conditions.Clinics in colon and rectal surgery · 2025
    Review
  16. Article
  17. Review
  18. Integrative Treatment Strategies for Chronic Back Pain: A Literature Review with Clinical Recommendations.International journal of environmental research and public health · 2025
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sarah BannonIntegrated Brain Health Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Jonathan GreenbergIntegrated Brain Health Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Ryan A MaceIntegrated Brain Health Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Joseph J LocascioHarvard Medical School, Boston, MA, USA; Department of Biostatistics, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Ana-Maria VranceanuIntegrated Brain Health Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: avranceanu@mgh.harvard.edu.
Harvard University · USMassachusetts General Hospital · US

Funding

Integrating Mind Body Skills with Physical Activity to Improve Pain Outcomes in Patients with Heterogeneous Chronic Pain ConditionsR34AT009356 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI VRANCEANU, ANA-MARIA · 2017 to 2019
$1.2M
NCCIH NIH HHS R34 AT009356
6 · The paper itself

Abstract

objectiveSocial isolation negatively impacts early-disease processes and long-term health. Individuals with chronic pain are more vulnerable to social isolation, which exacerbates symptoms. It is currently unclear whether: 1. group-based programs for chronic pain improve social isolation, 2. improvements in social isolation account for improvements in outcomes. This study involved secondary data analysis of participants in a 10-week mind-body physical activity program. We examined whether social isolation improved during treatment, and whether such improvements accounted for improvements in emotional and physical functioning.

methodsParticipants (N = 82) with chronic pain were randomized to a group-based mind-body physical activity intervention with (GetActive-Fitbit; n = 41) or without a Fitbit device (GetActive; n = 41). Participants completed self-reported measures of social isolation, emotional functioning (depression and anxiety symptoms), and multimodal physical functioning (self-report, performance-based, and objective). We used linear mixed effects modeling to examine pre-post treatment changes in social isolation and whether these changes accounted for improvements in emotional and physical functioning.

resultsBoth interventions were associated with significant and comparable improvements in social isolation from baseline to end of treatment, and improvements in social isolation accounted for significant improvements in self-reported emotional and physical functioning.

conclusionInterventions may target social isolation in chronic pain to optimize treatment outcomes.

Indexed as

Chronic PainAnxietyHumansSocial IsolationTreatment OutcomeAnxietyChronic painDepressionMind-bodyPhysical functionSocial isolationTrail registration:ClinicalTrials.govNCT03412916clinicaltrials.gov/ct2/show/NCT034129

Identifiers

PMID33540223
PMCPMC7979493
OpenAlexW3123380571

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.