Evidence map›Paper›PMID 33539947›Full record

ArticleFree radical biology & medicine2021

Endothelial-transcytosed myeloperoxidase activates endothelial nitric oxide synthase via a phospholipase C-dependent calcium signaling pathway.

Thuan Thai, Fei Zhong, Lei Dang, Enoch Chan, Jacqueline Ku, Ernst Malle, Carolyn L Geczy, John F Keaney, Shane R Thomas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  3. Article
  4. Article
  5. Nitric Oxide Synthases in Rheumatoid Arthritis.Molecules (Basel, Switzerland) · 2023
    Review
  6. Review
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Thuan ThaiSchool of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia; School of Education, University of Notre Dame Australia, Sydney, NSW, Australia.
Fei ZhongSchool of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Lei DangSchool of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Enoch ChanSchool of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Jacqueline KuSchool of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Ernst MalleGottfried Schatz Research Center, Division of Molecular Biology & Biochemistry, Medical University of Graz, Graz, Austria.
Carolyn L GeczySchool of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
John F KeaneyCardiovascular Medicine, Brigham and Women's Hospital, Harvard University, Boston, MA, USA.
Shane R ThomasSchool of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. Electronic address: shane.thomas@unsw.edu.au.
UNSW Sydney · AUBrigham and Women's Hospital · USMedical University of Graz · AT

Funding

SIRT1, Polyphenols, and Endothelial OxidantsP01HL068758 · NHLBI · BOSTON MEDICAL CENTER · PI SAHA, ASISH K. · 2003 to 2013
$14.1M
Vitamin C, glutathione and NO action in humansP01HL060886 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI VITA, JOSEPH A. · 2000 to 2004
$5.4M
NHLBI NIH HHS P01 HL060886NHLBI NIH HHS P01 HL068758
6 · The paper itself

Abstract

During vascular inflammation, the leukocyte-derived enzyme myeloperoxidase (MPO) is transcytosed across the endothelium and into the sub-endothelial extracellular matrix, where it promotes endothelial dysfunction by catalytically consuming nitric oxide (NO) produced by endothelial NO synthase (eNOS). In the presence of chloride ions and hydrogen peroxide (H

Indexed as

Nitric Oxide Synthase Type IIIPeroxidaseCalciumCalcium SignalingEndothelial CellsEndothelium, VascularHydrogen PeroxideType C PhospholipasesCalciumHydrogen PeroxideNitric Oxide Synthase Type IIIPeroxidaseType C PhospholipasesEndothelial dysfunctionEndothelial nitric oxide synthaseHydrogen peroxideHypochlorous acidl-arginineMyeloperoxidaseNitric oxideOxidative stressReactive oxygen speciesRedox signaling

Identifiers

PMID33539947
PMCPMC10686581
OpenAlexW3126919941

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.