ArticleThe Journal of biological chemistry
KCC2 is required for the survival of mature neurons but not for their development.
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Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 19 citations in OpenAlex.
- Molecular pathways underlying amyloid precursor protein-mediated regulation of adult-born neurons.Neural regeneration research · 2026Article
- Allele specific expression in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Neural Correlates of Huntington's Disease Based on Electroencephalography (EEG): A Mechanistic Review and Discussion of Excitation and Inhibition (E/I) Imbalance.Journal of clinical medicine · 2025Review
- KCC2 inhibition and neuronal hyperexcitability promote extrinsic apoptosis dependent upon C1q.Frontiers in molecular neuroscience · 2025Article
- ETV4‑mediated transcriptional activation of SLC12A5 exacerbates ferroptosis resistance and glucose metabolism reprogramming in breast cancer cells.Molecular medicine reports · 2024Article
- The brain-specific kinase LMTK3 regulates neuronal excitability by decreasing KCC2-dependent neuronal CliScience · 2024Article
- Neuronal KActa pharmacologica Sinica · 2024Review
- Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice.Cell reports. Medicine · 2023Article
- Spectrin-beta 2 facilitates the selective accumulation of GABACommunications biology · 2023Article
- KFrontiers in cellular neuroscience · 2023Article
- Layer-specific changes of KCC2 and NKCC1 in the mouse dentate gyrus after entorhinal denervation.Frontiers in molecular neuroscience · 2023Article
- Long March Toward Safe and Effective Analgesia by Enhancing Gene Expression ofFrontiers in molecular neuroscience · 2022Review
- Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons.Frontiers in molecular neuroscience · 2022Article
- Imbalance between the function of NaFrontiers in molecular neuroscience · 2022Article
- Analyzing the mechanisms that facilitate the subtype-specific assembly ofFrontiers in molecular neuroscience · 2022Article
- Role of GABAFrontiers in cellular neuroscience · 2022Article
- Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission.Nature communications · 2021Article
- Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency ThrPharmacological research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 3 countries.
Georgina KontouAstraZeneca-Tufts Laboratory of Basic and Translational Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
Shu Fun Josephine NgAstraZeneca-Tufts Laboratory of Basic and Translational Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
Ross A CardarelliAstraZeneca-Tufts Laboratory of Basic and Translational Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
Jack H HowdenDepartment of Neuroscience, Physiology, and Pharmacology, University College London, London, UK.
Catherine ChoiDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
Qiu RenDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
Miguel A Rodriguez SantosDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
Christopher E BopeDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
Jake S DenglerDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
Matt R KelleyDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
Paul A DaviesDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
Josef T KittlerDepartment of Neuroscience, Physiology, and Pharmacology, University College London, London, UK.
Nicholas J BrandonAstraZeneca-Tufts Laboratory of Basic and Translational Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA.
Stephen J MossAstraZeneca-Tufts Laboratory of Basic and Translational Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA; Department of Neuroscience, Physiology, and Pharmacology, University College London, London, UK. Electronic address: Stephen.Moss@Tufts.edu.
Joshua L SmalleyDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
Tufts University · USUniversity College London · GB
Funding
Mechanisms that determine Glutamine synthetase activity in the brainR01NS081986 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2012 to 2022
$3.7MConstructing inhibitory synapsesR01NS051195 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MOSS, STEPHEN J · 2006 to 2014
$3.2MNovel actions of neurosteroids on GABA (A) receptor traffickingR01MH097446 · NIMH · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2013 to 2017
$2.1MNovel actions of neurosteroids on GABA (A) receptor traffickingR01NS108378 · NINDS · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2018 to 2022
$2.0MDeficits in KCC2 activity and the pathophysiology of Status EpilepticusR01NS087662 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2014 to 2018
$2.0MThe role of ubiquitination in regulating GABA(A) receptor functional expressionR01NS056359 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MOSS, STEPHEN J · 2007 to 2010
$1.4MDetermining the effects of human KCC2 mutations on neuronal excitabilityR21NS111338 · NINDS · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW · 2019 to 2020
$454kImpaired KCC2 function underlies pharmacoresistant seizuresR21NS080064 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2013 to 2014
$452kSensory Hypersensitivity in Fragile X Syndrome Due to Deficits in Tonic Inhibition Reversed by Neuroactive SteroidsR21NS111064 · NINDS · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW · 2020 to 2021
$450kNIMH NIH HHS R01 MH097446NINDS NIH HHS R01 NS051195NINDS NIH HHS R01 NS056359NINDS NIH HHS R01 NS081986NINDS NIH HHS R01 NS087662NINDS NIH HHS R01 NS108378NINDS NIH HHS R21 NS080064NINDS NIH HHS R21 NS111064NINDS NIH HHS R21 NS111338
Abstract
The K
Indexed as
AnimalsApoptosisChloridesFemalegamma-Aminobutyric AcidK Cl- CotransportersMaleMiceMice, Inbred C57BLMice, KnockoutNeurogenesisNeuronsPotassiumPrimary Cell CultureReceptors, GABASeizuresChloridesgamma-Aminobutyric AcidK Cl- CotransportersPotassiumReceptors, GABASymportersapoptosiscell deathextrinsic pathwayKCC2seizures
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.