Evidence map›Paper›PMID 33539857›Full record

ArticleThe American journal of cardiology2021

Relation of Cardiovascular Risk Factors to Mortality and Cardiovascular Events in Hospitalized Patients With Coronavirus Disease 2019 (from the Yale COVID-19 Cardiovascular Registry).

Manan Pareek, Avinainder Singh, Lina Vadlamani, Maxwell Eder, Justin Pacor, Jakob Park, Zaniar Ghazizadeh, Alex Heard, Ana Sofia Cruz-Solbes, Roozbeh Nikooie and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Venous thromboembolism and major adverse cardiovascular events in patients with hip fractures suffering from SARS-CoV-2 infection: a systematic review.Hip international : the journal of clinical and experimental research on hip pathology and therapy · 2023
    Pooled it
  2. Pooled it
  3. Article
  4. SARS-CoV-2 and Environmental Changes: The Perfect Storm.Current issues in molecular biology · 2024
    Review
  5. Article
  6. CT-Angiographic Aspects of Pulmonary Embolism on SARS COV-2.Journal of the Belgian Society of Radiology · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Observational
  11. Hyperlipidemia, COVID-19 and acute pancreatitis: A tale of three entities.The American journal of the medical sciences · 2022
    Review
  12. Clinical outcomes of COVID-19 infection in patients with pre-existing cardiovascular disease.American heart journal plus : cardiology research and practice · 2022
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Manan PareekDepartment of Internal Medicine, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Avinainder SinghDepartment of Internal Medicine, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Lina VadlamaniDepartment of Internal Medicine, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Maxwell EderDepartment of Internal Medicine, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Justin PacorDepartment of Internal Medicine, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Jakob ParkDepartment of Internal Medicine, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Zaniar GhazizadehDepartment of Internal Medicine, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Alex HeardDepartment of Internal Medicine, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Ana Sofia Cruz-SolbesDepartment of Internal Medicine, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Roozbeh NikooieDepartment of Internal Medicine, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Chad GierDepartment of Internal Medicine, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Zain V AhmedDepartment of Cardiology, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
James V FreemanDepartment of Cardiology, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Judith MeadowsDepartment of Internal Medicine, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Kim G E SmolderenDepartment of Cardiology, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Rachel LampertDepartment of Cardiology, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Eric J VelazquezDepartment of Cardiology, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Tariq AhmadDepartment of Cardiology, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Nihar R DesaiDepartment of Cardiology, Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut. Electronic address: nihar.desai@yale.edu.
Yale New Haven Hospital · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NIA Short Term Research Training: Students in Health Professional SchoolsT35AG049685 · NIA · YALE UNIVERSITY · PI Sarwat I Chaudhry, Terri R. Fried · 2016 to 2026
$804k
NCATS NIH HHS UL1 TR001863NIA NIH HHS T35 AG049685
6 · The paper itself

Abstract

Individuals with established cardiovascular disease or a high burden of cardiovascular risk factors may be particularly vulnerable to develop complications from coronavirus disease 2019 (COVID-19). We conducted a prospective cohort study at a tertiary care center to identify risk factors for in-hospital mortality and major adverse cardiovascular events (MACE; a composite of myocardial infarction, stroke, new acute decompensated heart failure, venous thromboembolism, ventricular or atrial arrhythmia, pericardial effusion, or aborted cardiac arrest) among consecutively hospitalized adults with COVID-19, using multivariable binary logistic regression analysis. The study population comprised 586 COVID-19 positive patients. Median age was 67 (IQR: 55 to 80) years, 47.4% were female, and 36.7% had cardiovascular disease. Considering risk factors, 60.2% had hypertension, 39.8% diabetes, and 38.6% hyperlipidemia. Eighty-two individuals (14.0%) died in-hospital, and 135 (23.0%) experienced MACE. In a model adjusted for demographic characteristics, clinical presentation, and laboratory findings, age (odds ratio [OR], 1.28 per 5 years; 95% confidence interval [CI], 1.13 to 1.45), previous ventricular arrhythmia (OR, 18.97; 95% CI, 3.68 to 97.88), use of P2Y

Indexed as

RegistriesAgedAged, 80 and overCardiovascular DiseasesComorbidityCOVID-19FemaleHospital MortalityHumansMaleMiddle AgedProspective StudiesRisk FactorsSARS-CoV-2Survival RateUnited States

Identifiers

PMID33539857
PMCPMC7849530
OpenAlexW3129176577

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.