ArticleCell stem cell2021
Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity.
Open access · bronzeAbstract read
In one paragraph
Article in Cell stem cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
8.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- An integrated single cell and spatial transcriptomic map of human white adipose tissue.Nature communications · 2023Pooled it
- Review
- Adipocyte Expression of O-Glycoprotein Procollagen C-Endopeptidase Enhancer Protein 2 (PCPE2): Mechanisms Linking Fibrosis and Beiging of White Adipose Tissue.bioRxiv : the preprint server for biology · 2026Article
- Legacy Effects of Early β-Adrenergic Stimulation Program Adipose Plasticity and Confer Metabolic Resilience in Obesity.bioRxiv : the preprint server for biology · 2026Article
- Hypoxia-inducible factor 1αa regulates lipid metabolism to coordinate adipocyte hypertrophy and hyperplasia in grass carp.The Journal of biological chemistry · 2026Article
- Article
- Netrin-1 disrupt high-fat-diet-induced adipogenesis via the PPARγ and Wnt/β-catenin signaling pathways.Communications biology · 2026Article
- Bifurcate Regulation of Hematopoietic Homeostasis and Bone Osteogenesis by VHL-HIF2α-Controlled Adipocyte Function.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Single-cell-resolved transcriptional dynamics of human subcutaneous adipose tissue during lifestyle- and bariatric surgery-induced weight loss.Nature metabolism · 2026Article
- Quantitative lipidomic analysis reveals distinct metabolic traits between stromal cell subpopulations in human orbital adipose tissue.Metabolism open · 2025Article
- Article
- Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health.Nature reviews. Endocrinology · 2025Review
- Distinct adipose progenitor cells emerging with age drive active adipogenesis.Science (New York, N.Y.) · 2025Article
- Hypoxia signaling in the adipose tissue.Journal of molecular cell biology · 2025Review
- Macrophage Phenotypic Switch and Obesity-Associated Metabolic Risk: Mechanisms and Targets.Oxidative medicine and cellular longevity · 2025Review
- snRNA-seq reveals subcutaneous white adipose tissue remodeling upon return to thermoneutrality after cold stimulation.Frontiers in cell and developmental biology · 2025Article
- Amphiphilic cytokine traps remodel marrow adipose tissue for hematopoietic microenvironment amelioration.Bioactive materials · 2024Article
- Contribution of glucose and glutamine to hypoxia-induced lipid synthesis decreases, while contribution of acetate increases, during 3T3-L1 differentiation.Scientific reports · 2024Article
- Lipid synthesis, triggered by PPARγ T166 dephosphorylation, sustains reparative function of macrophages during tissue repair.Nature communications · 2024Article
- PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels.Nature metabolism · 2024Article
Corrections and comments
- Commented on by
Authors and funding
11 authors at 2 institutions in 2 countries.
Mengle ShaoTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Chelsea HeplerTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Qianbin ZhangTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Bo ShanTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Lavanya VishvanathTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Gervaise H HenryDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Shangang ZhaoTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Yu A AnTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Yibo WuYCI Laboratory for Next-Generation Proteomics, RIKEN Center of Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Douglas W StrandDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Rana K GuptaTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: rana.gupta@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · USRIKEN Center for Integrative Medical Sciences · JP
Funding
Generation of Novel Genetic Tools to Study Cellular Heterogeneity in Adipose TissuesRC2DK118620 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GUPTA, RANA K, SCHERER, PHILIPP E · 2019 to 2023
$7.0MEstablishment and Maintenance of Healthy Adipose Tissue in ObesityR01DK104789 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GUPTA, RANA K · 2015 to 2024
$3.9MNotch-mediated 5ARI resistance in human BPHR01DK115477 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI STRAND, DOUGLAS WILLIAM · 2018 to 2022
$1.9MMultifaceted Roles for Pdgfrb+ Perivascular Cells in White Adipose Tissue RemodelingR01DK119163 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GUPTA, RANA K · 2019 to 2022
$1.8MLaser Scanning Confocal for UT Southwestern Live Cell Imaging FacilityS10OD021684 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2016 to 2016
$455kMural Cell Zfp423 in Control of Adipose Remodeling in ObesityF31DK113696 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI HEPLER, CHELSEA · 2017 to 2018
$51kNIDDK NIH HHS F31 DK113696NIDDK NIH HHS R01 DK104789NIDDK NIH HHS R01 DK115477NIDDK NIH HHS R01 DK119163NIDDK NIH HHS RC2 DK118620NIH HHS S10 OD021684
Abstract
Adipose precursor cells (APCs) exhibit regional variation in response to obesity, for unclear reasons. Here, we reveal that HIFα-induced PDGFRβ signaling within murine white adipose tissue (WAT) PDGFRβ
Indexed as
AdipogenesisAdipose TissueAdipocytesAdipose Tissue, WhiteAnimalsDiet, High-FatMiceMice, Inbred C57BLObesityAdipocyte precursor cellAdipogenesisFibrosisHIF1αImatinibPDGFRPPARγ
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.