ArticleChemistry (Weinheim an der Bergstrasse, Germany)2021
A Titanium-Catalyzed Reductive α-Desulfonylation.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 19 citations in OpenAlex.
- Titanium-Catalyzed Diastereoselective Keto- and Iminonitrile Cyclizations.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Titanium-Mediated Organic Electrosynthesis.ACS catalysis · 2025Review
- Article
- A Titanium-Catalyzed Reductive α-Desulfonylation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
A titanium(III)-catalyzed desulfonylation gives access to functionalized alkyl nitrile building blocks from α-sulfonyl nitriles, circumventing traditional base-mediated α-alkylation conditions and strong single electron donors. The reaction tolerates numerous functional groups including free alcohols, esters, amides, and it can be applied also to the α-desulfonylation of ketones. In addition, a one-pot desulfonylative alkylation is demonstrated. Preliminary mechanistic studies indicate a catalyst-dependent mechanism involving a homolytic C-S cleavage.
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