ArticlePloS one2021
Polycystic ovary syndrome and extremely preterm birth: A nationwide register-based study.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- How Pre-Pregnancy Weight and Polycystic Ovary Syndrome Impact Pregnancy Outcomes: A Population-Based Cohort Study.Health science reports · 2026Article
- Menstrual cycle length identifies perinatal risk information beyond routine metabolic antenatal screening: a retrospective cohort study of 17,792 deliveries.Frontiers in endocrinology · 2026Article
- Review
- Gestational diabetes mellitus and polycystic ovary syndrome, a position statement from EGOI-PCOS.Frontiers in endocrinology · 2025Review
- Adverse Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome with Pre-Conceptional Hyperandrogenism: A Multi-Institutional Registry-Based Retrospective Cohort Study.Journal of clinical medicine · 2024Article
- Ovulation induction and subfertile untreated conception groups offer improved options for interpreting risks associated with ART.Journal of assisted reproduction and genetics · 2024Article
- Associations between neighborhood stress and maternal sex steroid hormones in pregnancy.BMC pregnancy and childbirth · 2023Article
- Nomogram for predicting the risk of preterm birth in women undergoing in vitro fertilization cycles.BMC pregnancy and childbirth · 2023Article
- Nomogram for predicting the risk of preterm delivery after IVF/ICSI treatment: an analysis of 11513 singleton births.Frontiers in endocrinology · 2023Article
- Birth outcomes in mothers with hypertensive disorders and polycystic ovary syndrome: a population-based cohort study.Human reproduction open · 2023Article
- Maternal factors during pregnancy influencing maternal, fetal, and childhood outcomes.BMC medicine · 2022Article
- Polycystic ovary syndrome and risk of adverse pregnancy outcomes: a registry linkage study from Massachusetts.Human reproduction (Oxford, England) · 2022Observational
- Polycystic ovary syndrome and risk of adverse obstetric outcomes: a retrospective population-based matched cohort study in England.BMC medicine · 2022Article
- Association of maternal polycystic ovary syndrome and diabetes with preterm birth and offspring birth size: a population-based cohort study.Human reproduction (Oxford, England) · 2022Article
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8 authors.
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Abstract
introductionWomen with polycystic ovary syndrome (PCOS) have increased risk of pregnancy complications, including preterm birth before 37 weeks. However, if this increased risk also includes extremely preterm births (<28 weeks) is unknown. Such information is important to identify women at risk and tailor antenatal care, since child morbidity and mortality become more prevalent with increasing prematurity.
aimsTo investigate the association between PCOS and extremely preterm birth, and whether onset of PCOS-related preterm birth is predominantly spontaneous or medically indicated. MATERIAL AND
methodsThis was a nationwide register-based cohort study in Sweden. The study population was all live singleton births registered in the Swedish Medical Birth Register 2005-2014 (n = 1 046 448). Women with and without PCOS were compared by severity of preterm birth [extremely (22+0 to 27+6 weeks), very (28+0 to 31+6 weeks) and moderately (32+0 to 36+6 weeks)] and delivery onset mode (spontaneous or medically indicated). Multinomial logistic regression was performed to estimate adjusted odds ratios (aOR) with 95% confidence intervals (CI). Adjustments were made for maternal age, parity, body mass index, smoking, country of birth and year of delivery.
resultsDuring the study period, 1.3% of the women giving birth had PCOS diagnosis. They had an overall higher preterm birth rate than women without PCOS (6.7% and 4.8%, respectively). Women with PCOS had increased odds of preterm birth of all severities, with the highest odds for extremely preterm birth (aOR 2.3; 95% CI 1.7-3.0), particularly of spontaneous onset (aOR 2.7; 95% CI 2.0-3.6).
conclusionsWomen with PCOS had more than a two-fold increased risk of extremely preterm birth with spontaneous onset than women without such diagnosis. This can be important in antenatal risk assessment of preterm birth in women with PCOS. Future research is warranted to investigate the biological mechanisms behind preterm birth in women with PCOS.
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