ArticlePloS one2021
Integration of metabolomics and existing omics data reveals new insights into phytoplasma-induced metabolic reprogramming in host plants.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Potato purple top phytoplasma infection induces autophagy-associated lipid dynamics that support pathogen proliferation.Plant physiology · 2026Article
- Integrated carbon metabolism-transcriptomics-proteomics reveals physiological and molecular mechanisms underlying sour jujube resistance to witches' broom disease.BMC plant biology · 2026Article
- Microbial diversity of plant pathogens and insect endosymbionts in Reptalus artemisiae.BMC microbiology · 2026Article
- Exploring dynamic changes in metabolic profiles ofFrontiers in plant science · 2026Article
- 'Candidatus Phytoplasma mali' SAP11-Like protein modulates expression of genes involved in energy production, photosynthesis, and defense in Nicotiana occidentalis leaves.BMC plant biology · 2024Article
- Differential Symptomology, Susceptibility, and Titer Dynamics Manifested by Phytoplasma-Infected Periwinkle and Tomato Plants.Plants (Basel, Switzerland) · 2024Article
- 'Insects · 2023Article
- The Endoplasmic Reticulum Is a Key Battleground between Phytoplasma Aggression and Host Plant Defense.Cells · 2023Article
- Signaling Cross-Talk between Salicylic and Gentisic Acid in the 'Plants (Basel, Switzerland) · 2023Article
- Jujube Fruit Metabolomic Profiles Reveal Cultivar Differences and Function as Cultivar Fingerprints.Plants (Basel, Switzerland) · 2023Article
- Article
- Candidate pathogenicity factor/effector proteins of 'Frontiers in plant science · 2023Article
- Effects of Poty-Potexvirus Synergism on Growth, Photosynthesis and Metabolite Status ofViruses · 2022Article
- Review
- Effect of Phytoplasma Associated with Sesame Phyllody on Ultrastructural Modification, Physio-Biochemical Traits, Productivity and Oil Quality.Plants (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytoplasmas are cell wall-less bacteria that induce abnormal plant growth and various diseases, causing severe economic loss. Phytoplasmas are highly dependent on nutrients imported from host cells because they have lost many genes involved in essential metabolic pathways during reductive evolution. However, metabolic crosstalk between phytoplasmas and host plants and the mechanisms of phytoplasma nutrient acquisition remain poorly understood. In this study, using metabolomics approach, sweet cherry virescence (SCV) phytoplasma-induced metabolite alterations in sweet cherry trees were investigated. A total of 676 metabolites were identified in SCV phytoplasma-infected and mock inoculated leaves, of which 187 metabolites were differentially expressed, with an overwhelming majority belonging to carbohydrates, fatty acids/lipids, amino acids, and flavonoids. Available omics data of interactions between plant and phytoplasma were also deciphered and integrated into the present study. The results demonstrated that phytoplasma infection promoted glycolysis and pentose phosphate pathway activities, which provide energy and nutrients, and facilitate biosynthesis of necessary low-molecular metabolites. Our findings indicated that phytoplasma can induce reprograming of plant metabolism to obtain nutrients for its own replication and infection. The findings from this study provide new insight into interactions of host plants and phytoplasmas from a nutrient acquisition perspective.
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