Evidence map›Paper›PMID 33539264›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2021

Olfactory receptor 78 regulates erythropoietin and cardiorespiratory responses to hypobaric hypoxia.

Benjamin Wang, Ying-Jie Peng, Xiaoyu Su, Chongxu Zhang, Jason S Nagati, Joseph A Garcia, Nanduri R Prabhakar

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Adrenal epinephrine facilitates erythropoietin gene activation by hypoxia through β2 adrenergic receptor interaction with Hif-2α.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Hypoxia sensing requires HScience advances · 2023
    Article
  8. A pleiotropic hypoxia-sensitiveScience advances · 2022
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Benjamin WangInstitute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, Illinois.
Ying-Jie PengInstitute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, Illinois.
Xiaoyu SuInstitute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, Illinois.
Chongxu ZhangInstitute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, Illinois.
Jason S NagatiDepartment of Medicine, Division of Cardiology, Columbia University, New York, New York.
Joseph A GarciaDepartment of Medicine, Division of Cardiology, Columbia University, New York, New York.
Nanduri R PrabhakarInstitute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, Illinois.ORCID 0000-0003-4570-1380
University of Chicago · USColumbia University · US

Funding

Mechanisms Underlying Sympathetic Activation-dependent Endothelial Cell Activation by Chronic Intermittent HypoxiaP01HL144454 · NHLBI · UNIVERSITY OF CHICAGO · PI PRABHAKAR, NANDURI R · 2019 to 2023
$12.7M
Integrative Training in the Neurobiology of Addictive BehaviorsT32DA043469 · NIDA · UNIVERSITY OF CHICAGO · PI Donald Hedeker, Xiaoxi Zhuang · 2017 to 2026
$3.8M
Mechanistic Studies and Translational Applications of Stress Signaling in AnemiaR01HL130142 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GARCIA, JOSEPH ANTHONY · 2016 to 2019
$1.6M
ENDOTHELIAL CELL BIOLOGY FOLLOWING OXIDATIVE STRESSR01HL044454 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI BARCHOWSKY, AARON · 1991 to 1993
–
BLRD VA I01 BX000446NHLBI NIH HHS P01 HL144454NHLBI NIH HHS P01-HL-44454NHLBI NIH HHS R01 HL130142NIDA NIH HHS T32 DA043469
6 · The paper itself

Abstract

Olfactory receptor (Olfr) 78 is expressed in the carotid bodies (CB) and participates in CB responses to acute hypoxia. Olfr78 is also expressed in the kidney, which is a major site of erythropoietin (Epo) production by hypoxia. The present study examined the role of Olfr78 in cardiorespiratory and renal

Indexed as

Carotid BodyErythropoietinReceptors, OdorantAnimalsHypoxiaMaleMiceRespirationErythropoietinOlfr78 protein, mouseReceptors, Odorantcarotid bodyerythropoietinhigh-altitude adaptationhypertensionsympathetic nervous system

Identifiers

PMID33539264
PMCPMC8262783
OpenAlexW3128686966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.