Evidence map›Paper›PMID 33539068›Full record

ArticleAnalytical chemistry2021

Clinical-Scale Production of Nearly Pure (>98.5%) Parahydrogen and Quantification by Benchtop NMR Spectroscopy.

Shiraz Nantogma, Baptiste Joalland, Ken Wilkens, Eduard Y Chekmenev

Abstract read
In one paragraph

Article in Analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Biocompatible SABRE Hyperpolarization of [1-Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  2. High-resolution microtesla in-situJournal of magnetic resonance (San Diego, Calif. : 1997) · 2026
    Article
  3. Multidimensional pH-Temperature Mapping of SABRE-SHEATHThe journal of physical chemistry. B · 2025
    Article
  4. The journal of physical chemistry. B · 2025
    Article
  5. Article
  6. SABRE Ir-IMes Catalysis for the Masses.Molecules (Basel, Switzerland) · 2025
    Article
  7. EfficientJournal of magnetic resonance open · 2025
    Article
  8. Article
  9. Parahydrogen-Hyperpolarized Propane-The journal of physical chemistry. A · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Toward Ultra-High-Quality-Factor Wireless Masing Magnetic Resonance Sensing.Angewandte Chemie (International ed. in English) · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Journal of the American Chemical Society · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shiraz NantogmaDepartment of Chemistry, Integrative Biosciences (Ibio), Wayne State University, Detroit, Michigan 48202, United States.
Baptiste JoallandDepartment of Chemistry, Integrative Biosciences (Ibio), Wayne State University, Detroit, Michigan 48202, United States.ORCID 0000-0003-4116-6122
Ken WilkensDepartment of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science (VUIIS), Nashville, Tennessee 37232-2310, United States.
Eduard Y ChekmenevDepartment of Chemistry, Integrative Biosciences (Ibio), Wayne State University, Detroit, Michigan 48202, United States.ORCID 0000-0002-8745-8801

Funding

Hyperpolarized Diethyl Ether for Sub-second Pulmonary MRIR21HL154032 · NHLBI · WAYNE STATE UNIVERSITY · PI CHEKMENEV, EDUARD · 2020 to 2021
$419k
Magnetic Resonance Spectroscopy and Molecular Imaging of Metabolic Pathways in CancerR21CA220137 · NCI · WAYNE STATE UNIVERSITY · PI CHEKMENEV, EDUARD · 2017 to 2019
$390k
NCI NIH HHS R21 CA220137NHLBI NIH HHS R21 HL154032
6 · The paper itself

Abstract

Because of the extensive chemical, physical, and biomedical applications of parahydrogen, the need exists for the development of highly enriched parahydrogen in a robust and efficient manner. Herein, we present a parahydrogen enrichment equipment which substantially improves upon the previous generators with its ability to enrich parahydrogen to >98.5% and a production rate of up to 4 standard liters per minute with the added advantage of real-time quantification. Our generator employs a pulsed injection system with a 3/16 in. outside diameter copper spiral tubing filled with iron-oxide catalyst. This tubing is mated to a custom-made copper attachment to provide efficient thermal coupling to the cold head. This device allows for robust operation at high pressures up to 34 atm. Real-time quantification by benchtop NMR spectroscopy is made possible by direct coupling of the

Indexed as

HydrogenMagnetic Resonance ImagingCatalysisMagnetic Resonance SpectroscopyHydrogen

Identifiers

PMID33539068
PMCPMC8011325

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.