Evidence map›Paper›PMID 33539063›Full record

ArticleACS chemical neuroscience2021

Radiochemical Synthesis and Evaluation in Non-Human Primates of 3-[

Nicolas J Guehl, Ramesh Neelamegam, Yu-Peng Zhou, Sung-Hyun Moon, Maeva Dhaynaut, Georges El Fakhri, Marc D Normandin, Pedro Brugarolas

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Evaluation ofACS chemical neuroscience · 2023
    Article
  5. Radiochemical Synthesis and Evaluation of 3-[ACS chemical neuroscience · 2022
    Article
  6. Article
  7. Bio-Evaluation ofFrontiers in medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nicolas J GuehlGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, United States.ORCID 0000-0001-6876-8292
Ramesh NeelamegamGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, United States.
Yu-Peng ZhouGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, United States.
Sung-Hyun MoonGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, United States.
Maeva DhaynautGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, United States.
Georges El FakhriGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, United States.
Marc D NormandinGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, United States.
Pedro BrugarolasGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, United States.ORCID 0000-0002-7455-2743
Harvard University · US

Funding

Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Georges El Fakhri · 2017 to 2026
$14.8M
Can [18F]3F4AP Detect Brain Demyelination? Evaluation of Novel PET Tracer in Nonhuman Primates and HumansR01NS114066 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BRUGAROLAS, PEDRO · 2020 to 2024
$1.8M
New tools for imaging: diagnostics based on therapeuticsR00EB020075 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BRUGAROLAS, PEDRO · 2017 to 2019
$747k
Gamma counter and continuous blood sampler for quantitative PET imagingS10OD018035 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI EL FAKHRI, GEORGES, NORMANDIN, MARC DAVID · 2014 to 2014
$144k
NIBIB NIH HHS P41 EB022544NIBIB NIH HHS R00 EB020075NIH HHS S10 OD018035NINDS NIH HHS R01 NS114066
6 · The paper itself

Abstract

Demyelination, the loss of the protecting sheath of neurons, contributes to disability in many neurological diseases. In order to fully understand its role in different diseases and to monitor treatments aiming at reversing this process, it would be valuable to have PET radiotracers that can detect and quantify molecular changes involved in demyelination such as the uncovering and upregulation of the axonal potassium channels K

Indexed as

Positron-Emission TomographyPotassium Channels4-AminopyridineAnimalsBrainHaplorhiniRadiochemistry4-AminopyridinePotassium Channelscarbon-11DemyelinationK+ channelsPETpharmacokineticsradiochemistry

Identifiers

PMID33539063
PMCPMC8060895
OpenAlexW3126737577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.