Evidence map›Paper›PMID 33538693›Full record

ArticleeLife2021

Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in

Evelyn L Eastwood, Kayla A Jara, Susanne Bornelöv, Marzia Munafò, Vasileios Frantzis, Emma Kneuss, Elisar J Barbar, Benjamin Czech, Gregory J Hannon

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
8.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Review
  3. piRNA direct the chromatin reader to its genomic targets.bioRxiv : the preprint server for biology · 2026
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  5. Review
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  8. Article
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  12. Xplor-NIH: Better parameters and protocols for NMR protein structure determination.Protein science : a publication of the Protein Society · 2024
    Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Evelyn L EastwoodCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.ORCID 0000-0002-3932-0402
Kayla A Jara *Department of Biochemistry and Biophysics, Oregon State University, Corvallis, United States.ORCID 0000-0003-0406-2957
Susanne Bornelöv *Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.ORCID 0000-0001-9276-9981
Marzia MunafòCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.ORCID 0000-0002-2689-8432
Vasileios FrantzisCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.ORCID 0000-0002-3497-700X
Emma KneussCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.ORCID 0000-0003-0662-8539
Elisar J BarbarDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, United States.ORCID 0000-0003-4892-5259
Benjamin CzechCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.ORCID 0000-0001-8471-0007
Gregory J HannonCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.ORCID 0000-0003-4021-3898
University of Cambridge · GBOregon State University · US

Funding

Cancer Research UK 21143Cancer Research UK A21143Wellcome TrustWellcome Trust 110161/Z/15/Z
6 · The paper itself

Abstract

In animal gonads, the PIWI-interacting RNA (piRNA) pathway guards genome integrity in part through the co-transcriptional gene silencing of transposon insertions. In

Indexed as

DNA Transposable ElementsGene SilencingAnimalsDrosophila melanogasterDrosophila ProteinsDyneinsctp protein, DrosophilaDNA Transposable ElementsDrosophila ProteinsDyneinschromosomesco-transcriptional silencingdimerisationD. melanogastergene expressionheterochromatinLC8piRNA pathwaytransposon

Identifiers

PMID33538693
PMCPMC7861614
OpenAlexW3126375100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.