Evidence map›Paper›PMID 33538366›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

Leukocyte chemotactic receptor Fpr1 protects against aging-related posterior subcapsular cataract formation.

Ji-Liang Gao, Joseph D Weaver, Jingsheng Tuo, Long Q Wang, Marie Siwicki, Daryl Despres, Martin Lizak, Erich H Schneider, William Kovacs, Arvydas Maminishkis and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Ji-Liang GaoMolecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Joseph D WeaverMolecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Jingsheng TuoLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Long Q WangMolecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Marie SiwickiMolecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Daryl DespresMouse Imaging Facility, National Institutes of Health, Bethesda, MD, USA.
Martin LizakMouse Imaging Facility, National Institutes of Health, Bethesda, MD, USA.
Erich H SchneiderMolecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
William KovacsMolecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Arvydas MaminishkisSection on Epithelial and Retinal Physiology and Disease, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Keqiang ChenLaboratory of Cancer and Immunometabolism, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.
Teizo YoshimuraDepartment of Pathology and Experimental Medicine, Okayama University, Okayama, Japan.
Ji Ming WangLaboratory of Cancer and Immunometabolism, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.
Chi Chao ChanLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Philip M MurphyMolecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
National Institutes of Health · USNational Institute of Allergy and Infectious Diseases · USFrederick National Laboratory for Cancer Research · USNational Cancer Institute · USOkayama University · JP

Funding

Molecular Analysis Of Leukocyte Activation By ChemoattractantsZIAAI000615 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MURPHY, PHILIP · 2009 to 2025
$44.8M
Translational Research CoreZICEY000573 · NEI · NATIONAL EYE INSTITUTE · PI MAMINISHKIS, ARVYDAS · 2021 to 2025
$7.5M
MOLECULAR ANALYSIS OF NEUTROPHIL ACTIVATION BY CHEMOATTRACTANTSZ01AI000615 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI MURPHY, PHILIP · 1991 to 2008
$7.1M
Intramural NIH HHS Z01 AI000615
6 · The paper itself

Abstract

Cataracts are a common consequence of aging; however, pathogenesis remains poorly understood. Here, we observed that after 3 months of age mice lacking the G protein-coupled leukocyte chemotactic receptor Fpr1 (N-formyl peptide receptor 1) began to develop bilateral posterior subcapsular cataracts that progressed to lens rupture and severe degeneration, without evidence of either systemic or local ocular infection or inflammation. Consistent with this, Fpr1 was detected in both mouse and human lens in primary lens epithelial cells (LECs), the only cell type present in the lens; however, expression was confined to subcapsular LECs located along the anterior hemispheric surface. To maximize translucency, LECs at the equator proliferate and migrate posteriorly, then differentiate into lens fiber cells by nonclassical apoptotic signaling, which results in loss of nuclei and other organelles, including mitochondria which are a rich source of endogenous N-formyl peptides. In this regard, denucleation and posterior migration of LECs were abnormal in lenses from Fpr1

Indexed as

AgingAnimalsCataractCell DifferentiationCell ProliferationFlow CytometryGTP-Binding ProteinsHumansImmunohistochemistryMagnetic Resonance ImagingMiceMice, Inbred C57BLReceptors, Formyl PeptideUltrasonographyFpr1 protein, mouseGTP-Binding ProteinsReceptors, Formyl Peptidecataractchemoattractant receptoreyeformyl peptideG proteinknockout mouse

Identifiers

PMID33538366
PMCPMC11005932
OpenAlexW3126221597

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.