Evidence map›Paper›PMID 33538230›Full record

ArticleVirulence2021

Limiting protease production plays a key role in the pathogenesis of the divergent clinical isolates of

Joseph S Rom, Karen E Beenken, Aura M Ramirez, Christopher M Walker, Ethan J Echols, Mark S Smeltzer

Open access · goldAbstract read
In one paragraph

Article in Virulence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Microorganisms · 2025
    Review
  4. The ability ofInfection and immunity · 2025
    Article
  5. Microorganisms · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. The major role ofVirulence · 2023
    Article
  10. Article
  11. Article
  12. Biofilm and Small Colony Variants-An Update onInternational journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Joseph S RomDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences , Little Rock, Arkansas, USA.
Karen E BeenkenDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences , Little Rock, Arkansas, USA.
Aura M RamirezDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences , Little Rock, Arkansas, USA.
Christopher M WalkerDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences , Little Rock, Arkansas, USA.
Ethan J EcholsDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences , Little Rock, Arkansas, USA.
Mark S SmeltzerDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences , Little Rock, Arkansas, USA.
University of Arkansas for Medical Sciences · US

Funding

Arkansas Center for Clinical and Translational ResearchUL1TR000039 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$10.0M
Pilot Grant ProgramP30GM145393 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Jason S Stumhofer · 2022 to 2026
$7.6M
Impact of Staphylococcus aureus in osteomyelitis and bone physiologyR01AI119380 · NIAID · UNIV OF ARKANSAS FOR MED SCIS · PI BEENKEN, KAREN E., SMELTZER, MARK S · 2015 to 2025
$4.1M
Center for Protein Structure and FunctionP30GM103450 · NIGMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI MILLETT, FRANCIS S · 2012 to 2014
$3.2M
NCATS NIH HHS UL1 TR000039NIAID NIH HHS R01 AI119380NIGMS NIH HHS P30 GM103450NIGMS NIH HHS P30 GM145393
6 · The paper itself

Abstract

Using the USA300, methicillin-resistant

Indexed as

AnimalsBacterial ProteinsBiofilmsDisease Models, AnimalFemaleGene Expression Regulation, BacterialHumansMutationPeptide HydrolasesPhenotypeSepsisStaphylococcal InfectionsStaphylococcus aureusVirulenceBacterial ProteinsPeptide HydrolasesbiofilmcodYproteaserotsarAsepsissigBStaphylococcus aureusUAMS-1USA200

Identifiers

PMID33538230
PMCPMC7872036
OpenAlexW3127386282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.