SynthesisInternational wound journal2021
Microneedling in the treatment of atrophic scars: A systematic review of randomised controlled trials.
Synthesis in International wound journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Comparing fractional CO₂ laser and needling-based modalities in facial acne scar treatment: a comprehensive systematic review and meta-analysis.Lasers in medical science · 2026Pooled it
- A systematic review of comparative clinical trials on the efficacy, safety, and patient satisfaction of ablative and non-ablative laser therapies for atrophic, hypertrophic, and keloid scars.Lasers in medical science · 2025Pooled it
- Topical, light-based, and complementary interventions for acne: an overview of systematic reviews.The Cochrane database of systematic reviews · 2024Pooled it
- Microneedling Monotherapy for Acne Scar: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Aesthetic plastic surgery · 2022Pooled it
- Microneedling in the treatment of atrophic scars: A systematic review of randomised controlled trials.International wound journal · 2021Pooled it
- Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial.Lasers in medical science · 2025Trial
- Hydrogel microneedles functioning in pathological surroundings: where soft materials overcome hard scars.Materials today. Bio · 2026Review
- Comparative Efficacy of Combined Carbon Dioxide Fractional Laser and Pulse Dye Laser versus Monotherapy for Hypertrophic Scars: A Network Meta-Analysis of Randomized Controlled Trials.Aesthetic plastic surgery · 2026Review
- Microneedling Versus Chemical Peels for Atrophic Acne Scars: A Systematic Review and Meta-Analysis.Cureus · 2026Review
- Microneedling and Topical Retinyl Palmitate for Acne Scars: A Preliminary Split-Face Study with Placebo Control.Journal of clinical medicine · 2026Article
- Objective and Non-Invasive Evaluation of Fascial Layers Related to Surgical or Post-Traumatic Scars: A Systematic Review of the Literature.Life (Basel, Switzerland) · 2026Review
- Development and validation of a simplified pre-screening model for diabetic foot ulcer identification in diabetic patients.Frontiers in endocrinology · 2026Article
- Recent Progress on the Application of Microneedles for In Situ Sampling in Surface-Enhanced Raman Scattering Detection.Biosensors · 2025Review
- Red-Light Photodynamic Therapy with 10% Aminolevulinic Acid (ALA) Following Microneedling in the Treatment of Facial Actinic Keratosis: Cosmetic and Clinical Outcomes.The Journal of clinical and aesthetic dermatology · 2025Article
- Scar Management in Pediatric Patients.Medicina (Kaunas, Lithuania) · 2025Review
- Microneedle technology for enhanced topical treatment of skin infections.Bioactive materials · 2025Review
- Comparative study between fractional COArchives of dermatological research · 2025Article
- Chemical peeling in combination with microneedling versus chemical peeling or microneedling monotherapy in the treatment of acne scars: a systematic review and meta-analysis.Postepy dermatologii i alergologii · 2025Review
- Efficacy of fractional laser combined with bipolar radiofrequency in the treatment of atrophic facial acne scaring.American journal of translational research · 2025Article
- Microneedling with Topical Insulin Versus Microneedling with Non-Cross-Linked Hyaluronic Acid for Atrophic Post-Acne Scars: A Split-Face Study.Dermatology practical & conceptual · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, treatment of atrophic acne scars remains a therapeutic challenge for dermatologists, yet there is no standard option on the most effective treatment. Microneedling (MN) is a minimally invasive technology that involves repetitive skin puncture using sterile microneedles to disrupt dermal collagen that connects the scar tissue. Recent studies have demonstrated the potency of MN, such as dermaroller and fractionated microneedle radiofrequency, in the treatment of atrophic scars. The objective of this review is to evaluate systematically the current literature on MN for atrophic acne scars. A systematic search of literature was performed from PubMed, Medline, Cochrane Central, and Google Scholar databases for articles published during the last 20 years. Only randomised controlled trials (RCTs) with full-text version of the manuscript available were included in our study. Nine RCTs were included in this review. All treatment modalities demonstrated consistent results that MN was efficacious in treating atrophic acne scars as a monotherapy or in combination with other treatments. Moreover, no serious adverse effects were reported in all studies after MN treatment. MN is a well-tolerated and effective therapeutic modality in treating atrophic acne scars. Further research is required to validate the efficacy of MN with a larger sample size and lengthy follow-up.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.