ArticleBrain and behavior2021
Separating scale-free and oscillatory components of neural activity in schizophrenia.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Aperiodic Neural Activity in Clinical Investigations.The European journal of neuroscience · 2025Pooled it
- Diminished variability of alpha and beta band-limited power as a neural signature in schizophrenia.Translational psychiatry · 2026Article
- Global scale-free brain activity as a potential neural signature of visual information processing in aging.Frontiers in aging neuroscience · 2026Article
- The aperiodic and periodic activities of EEG dynamically relate with cognitive performance in schizophrenia.Schizophrenia research. Cognition · 2025Review
- Periodic and Aperiodic Alterations of Resting-State EEG in Schizophrenia Spectrum Disorders: Cognitive and Clinical Insights.The European journal of neuroscience · 2025Article
- Reduced temporal variability of cortical excitation/inhibition ratio in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- A General, Noise-Driven Mechanism for the 1/f-Like Behavior of Neural Field Spectra.Neural computation · 2024Article
- Neurophysiological avenues to better conceptualizing adaptive cognition.Communications biology · 2024Article
- Article
- The effect of aperiodic components in distinguishing Alzheimer's disease from frontotemporal dementia.GeroScience · 2024Article
- Resting-state fractal brain connectivity is associated with impaired cognitive performance in healthy aging.GeroScience · 2024Article
- Combining detrended cross-correlation analysis with Riemannian geometry-based classification for improved brain-computer interface performance.Frontiers in neuroscience · 2024Article
- The Scanner as the Stimulus: Deficient Gamma-BOLD Coupling in Schizophrenia at Rest.Schizophrenia bulletin · 2023Article
- Aperiodic Neural Activity is a Better Predictor of Schizophrenia than Neural Oscillations.Clinical EEG and neuroscience · 2023Article
- Electroencephalogram aperiodic power spectral slope can be reliably measured and predicts ADHD risk in early development.Developmental psychobiology · 2022Article
- Alpha blocking and 1/fβ spectral scaling in resting EEG can be accounted for by a sum of damped alpha band oscillatory processes.PLoS computational biology · 2022Article
- Fractal Structure of Brain Electrical Activity of Patients With Mental Disorders.Frontiers in physiology · 2022Article
- Scale-free and oscillatory spectral measures of sleep stages in humans.Frontiers in neuroinformatics · 2022Article
- Real-Time Algorithm for Detrended Cross-Correlation Analysis of Long-Range Coupled Processes.Frontiers in physiology · 2022Article
- Multiple-Resampling Cross-Spectral Analysis: An Unbiased Tool for Estimating Fractal Connectivity With an Application to Neurophysiological Signals.Frontiers in physiology · 2022Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlterations in narrow-band spectral power of electroencephalography (EEG) recordings are commonly reported in patients with schizophrenia (SZ). It is well established however that electrophysiological signals comprise a broadband scale-free (or fractal) component generated by mechanisms different from those producing oscillatory neural activity. Despite this known feature, it has not yet been investigated if spectral abnormalities found in SZ could be attributed to scale-free or oscillatory brain function.
methodsIn this study, we analyzed resting-state EEG recordings of 14 SZ patients and 14 healthy controls. Scale-free and oscillatory components of the power spectral density (PSD) were separated, and band-limited power (BLP) of the original (mixed) PSD, as well as its fractal and oscillatory components, was estimated in five frequency bands. The scaling property of the fractal component was characterized by its spectral exponent in two distinct frequency ranges (1-13 and 13-30 Hz).
resultsAnalysis of the mixed PSD revealed a decrease of BLP in the delta band in SZ over the central regions; however, this difference could be attributed almost exclusively to a shift of power toward higher frequencies in the fractal component. Broadband neural activity expressed a true bimodal nature in all except frontal regions. Furthermore, both low- and high-range spectral exponents exhibited a characteristic topology over the cortex in both groups.
conclusionOur results imply strong functional significance of scale-free neural activity in SZ and suggest that abnormalities in PSD may emerge from alterations of the fractal and not only the oscillatory components of neural activity.
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