Evidence map›Paper›PMID 33538063›Full record

ArticleMagnetic resonance in medicine2021

Rapid,

Jack J Miller, Ladislav Valkovič, Matthew Kerr, Kerstin N Timm, William D Watson, Justin Y C Lau, Andrew Tyler, Christopher Rodgers, Paul A Bottomley, Lisa C Heather and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  4. Rapid,Magnetic resonance in medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Jack J MillerDepartment of Physics, University of Oxford, Oxford, UK.ORCID 0000-0002-6258-1299
Ladislav ValkovičOxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Headington, Oxford, UK.ORCID 0000-0003-2567-3642
Matthew KerrDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Kerstin N TimmDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
William D WatsonOxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Headington, Oxford, UK.
Justin Y C LauDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.ORCID 0000-0001-7316-811X
Andrew TylerDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.ORCID 0000-0001-7013-2648
Christopher RodgersOxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Headington, Oxford, UK.ORCID 0000-0003-1275-1197
Paul A BottomleyOxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Headington, Oxford, UK.
Lisa C HeatherDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Damian J TylerDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
John Radcliffe Hospital · GBUniversity of Oxford · GBAarhus University · DKJohns Hopkins University · USSlovak Academy of Sciences · SKUniversity of Cambridge · GB

Funding

British Heart Foundation FS/14/17/30634British Heart Foundation FS/15/68/32042British Heart Foundation FS/16/7/31843British Heart Foundation FS/17/58/33072British Heart Foundation FS/19/18/34252British Heart Foundation RE/13/1/30181British Heart Foundation RG/11/9/28921Department of HealthWellcome TrustWellcome Trust 098436/Z/12/B
6 · The paper itself

Abstract

purposePhosphorus saturation-transfer experiments can quantify metabolic fluxes noninvasively. Typically, the forward flux through the creatine kinase reaction is investigated by observing the decrease in phosphocreatine (PCr) after saturation of γ-ATP. The quantification of total ATP utilization is currently underexplored, as it requires simultaneous saturation of inorganic phosphate (

methodsUsing a hybrid optimal-control and Shinnar-Le Roux method, a quasi-adiabatic RF pulse was designed for the dual saturation of PCr and

resultsThe quasi-adiabatic pulse was insensitive to a >2.5-fold variation in

conclusionsThis work demonstrates a novel quasi-adiabatic dual-saturation RF pulse with significantly improved performance that can be used to measure ATP turnover in the heart in vivo.

Indexed as

Adenosine TriphosphateMyocardiumAnimalsCreatine KinaseMagnetic Resonance SpectroscopyPhosphocreatineRatsAdenosine TriphosphateCreatine KinasePhosphocreatine31P-MRSATPcardiac metabolismCK-flux reactionCMRheartmetabolismPCrpulse designRF designsaturation transfer

Identifiers

PMID33538063
PMCPMC7986077
OpenAlexW3111344465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.