Evidence map›Paper›PMID 33538035›Full record

ArticleClinical cardiology2021

Impact of anemia on clinical outcomes of patients with atrial fibrillation: The COOL-AF registry.

Rungroj Krittayaphong, Satchana Pumprueg, Tomon Thongsri, Weerapan Wiwatworapan, Thaworn Choochunklin, Pontawee Kaewkumdee, Ahthit Yindeengam, COOL-AF Investigators

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Rungroj KrittayaphongDivision of Cardiology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.ORCID https://orcid.org/0000-0001-8684-2361
Satchana PumpruegDivision of Cardiology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Tomon ThongsriDepartment of Cardiology, Buddhachinaraj Hospital, Phitsanulok, Thailand.
Weerapan WiwatworapanDepartment of Cardiology, Maharat Nakorn Ratchasima Hospital, Nakorn Ratchasima, Thailand.
Thaworn ChoochunklinDeparment of Cardiology, Surin Hospital, Surin, Thailand.
Pontawee KaewkumdeeDivision of Cardiology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Ahthit YindeengamDivision of Cardiology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
COOL-AF Investigators
Siriraj Hospital · THBuddhachinaraj Hospital · THMaharat Nakhon Ratchasima Hospital · THSurin Hospital · TH

Funding

Health Systems Research Institute 59-053Heart Association of Thailand under the Royal Patronage of H.M the King
6 · The paper itself

Abstract

backgroundTo determine whether anemia is an independent risk factor for ischemic stroke and major bleeding in patients with non-valvular atrial fibrillation (NVAF). HYPOTHESIS: Anemia in patients with NVAF increase risk of clinical complications related to atrial fibrillation.

methodsWe conducted a prospective multicenter registry of patients with NVAF in Thailand. Demographic data, medical history, comorbid conditions, laboratory data, and medications were collected and recorded, and patients were followed-up every 6 months. The outcome measurements were ischemic stroke or transient ischemic attack (TIA), major bleeding, heart failure (HF), and death. All events were adjudicated by the study team. We analyzed whether anemia is a risk factor for clinical outcomes with and without adjusting for confounders.

resultsThere were a total of 1562 patients. The average age of subjects was 68.3 ± 11.5 years, and 57.7% were male. The mean hemoglobin level was 13.2 ± 1.8 g/dL. Anemia was demonstrated in 518 (33.16%) patients. The average follow-up duration was 25.8 ± 10.5 months. The rate of ischemic stroke/TIA, major bleeding, HF, and death was 2.9%, 4.9%, 1.8%, 8.6%, and 9.2%, respectively. Anemia significantly increased the risk of these outcomes with a hazard ratio of 2.2, 3.2, 2.9, 1.9, and 2.8, respectively. Oral anticoagulants (OAC) was prescribed in 74.8%; warfarin accounts for 89.9% of OAC. After adjusting for potential confounders, anemia remained a significant predictor of major bleeding, heart failure, and death, but not for ischemic stroke/TIA.

conclusionAnemia was found to be an independent risk factor for major bleeding, heart failure, and death in patients with NVAF.

Indexed as

AnemiaAtrial FibrillationStrokeAdministration, OralAnticoagulantsHumansMaleProspective StudiesRegistriesRisk FactorsWarfarinAnticoagulantsWarfarinanemiaatrial fibrillationbleedingclinical outcomesischemic strokeThailand

Identifiers

PMID33538035
PMCPMC7943899
OpenAlexW3127001613

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.