ArticleEndocrine2021
A comparative cross-sectional study on sleep quality in patients with a history of differentiated thyroid carcinoma and its correlation with quality of life.
Article in Endocrine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Health-Related Quality of Life following Total Thyroidectomy and Lobectomy for Differentiated Thyroid Carcinoma: A Systematic Review.Current oncology (Toronto, Ont.) · 2022Pooled it
- The relationship between sleep disturbances, depression and anxiety in differentiated thyroid cancer patients during radioiodine (131I) therapy: a longitudinal observational study.Frontiers in endocrinology · 2026Observational
- Factors Associated with Sleep Disruption and Fatigue in Thyroid Cancer Survivors.Current oncology (Toronto, Ont.) · 2025Article
- Sleep disorders in patients with differentiated thyroid cancer: a case-control study.Endocrine · 2025Article
- Assessing quality of life in papillary thyroid cancer through a cross-sectional comparative study of SF-26 versus ThyPRO questionnaire.Scientific reports · 2025Article
- Sleep quality during preparation for RAI: recombinant TSH vs. levothyroxine withdrawal.Frontiers in endocrinology · 2025Article
- The Relationship Between Thyroid Dysfunction and Sleep Quality Among Population of Saudi Arabia.International journal of general medicine · 2024Article
- The "not so good" thyroid cancer: a scoping review on risk factors associated with anxiety, depression and quality of life.Journal of medicine and life · 2023Article
- Mental Health in Postoperative Thyroid Patients During the COVID-19 Pandemic.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate sleep quality in differentiated thyroid carcinoma (DTC) patients and correlate sleep disturbances with quality of life (QoL).
methods119 DTC patients were enrolled (DTC group). The Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI) inventories were administered. The Thyroid-specific Patient-Reported Outcome (ThyPRO) questionnaire, the Billewicz scale (BS) and an ad-hoc visual analogic scale (VAS) were used to measure QoL and subjective therapy-related complaints. The same examinations were conducted in 53 subjects (control group) who had undergone surgery for benign thyroid pathology.
resultsL-T4 dosages and TSH levels differed between the groups. BS and VAS scores were comparable. PSQI documented a similar percentage of poor sleepers in the DTC (74%) and control (62%) groups. ISI showed no difference in subjects without clinically significant insomnia: DTC (43%) and controls (48%). ThyPRO showed significantly worse scores in DTC than control subjects. In DTC patients, PSQI (P = 0.002) and ISI (P = 0.04) correlated significantly with age. In control subjects, TSH displayed a significant positive association with PSQI (P = 0.02) and ISI (P < 0.05). The ThyPRO general score correlated significantly with PSQI in DTC patients. In both groups, ISI correlated significantly with several ThyPRO scales and the ThyPRO general score. "Anxiety" and "emotional susceptibility" were the scales most significantly related with PSQI and ISI.
conclusionIn disease-free DTC patients and subjects who undergo thyroid surgery for benign pathology, abnormal sleep components and insomnia are similar. The ThyPRO questionnaire closely reflects sleep disturbances in all subjects. Recognising and treating sleep disturbances might improve QoL.
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