Evidence map›Paper›PMID 33537929›Full record

ArticleIn vitro cellular & developmental biology. Animal2021

Hormesis of low-dose inhibition of pAkt1 (Ser473) followed by a great increase of proline-rich inositol polyphosphate 5-phosphatase (PIPP) level in oocytes.

Hang Yu, Wei Yong, Teng Gao, Man Na, Ye Zhang, Isaac Harlison Kuguminkiriza, Anyanyo Alexander Kenechukwu, Qingguo Guo, Guoli Zhang, Xin Deng

Abstract read
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In one paragraph

Article in In vitro cellular & developmental biology. Animal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Hang YuDepartment of Physics and Biophysics, School of Fundamental Sciences, China Medical University (CMU), Shenyang, 110122, People's Republic of China.
Wei YongCenter Laboratory of the Fourth Affiliated Hospital, China Medical University (CMU), Shenyang, 110032, People's Republic of China.
Teng GaoCenter Laboratory of the Fourth Affiliated Hospital, China Medical University (CMU), Shenyang, 110032, People's Republic of China.
Man NaCenter Laboratory of the Fourth Affiliated Hospital, China Medical University (CMU), Shenyang, 110032, People's Republic of China.
Ye ZhangCenter Laboratory of the Fourth Affiliated Hospital, China Medical University (CMU), Shenyang, 110032, People's Republic of China.
Isaac Harlison KuguminkirizaInternational Education School of CMU, Shenyang, 110032, People's Republic of China.
Anyanyo Alexander KenechukwuInternational Education School of CMU, Shenyang, 110032, People's Republic of China.
Qingguo GuoDepartment of Biochemistry and Molecular Biology, CMU, Shenyang, China.
Guoli ZhangInstitute of Veterinary Medicine, The Academy of Military Medical Sciences of PLA, Changchun, 130122, Jilin, People's Republic of China.
Xin DengCenter Laboratory of the Fourth Affiliated Hospital, China Medical University (CMU), Shenyang, 110032, People's Republic of China. xdeng@cmu.edu.cn.ORCID http://orcid.org/0000-0001-7846-7389
Fourth Affiliated Hospital of China Medical University · CNInternational Centre for Materials Physics · CNAcademy of Military Medical Sciences · CNChina Medical University · CN

Funding

National Natural Science Foundation of China 81370712
6 · The paper itself

Abstract

Hormesis describes a biphasic dose-response relationship generally characterized by a low-dose excitement and a high-dose inhibition. This phenomenon has been observed in the regulation of cell, organ, and organismic level. However, hormesis has not reported in oocytes. In this study, we observed, for the first time, hormetic responses of PIPP levels in oocytes by inhibitor of Akt1 or PKCδ. The expression of PIPP was detected by qPCR, immunofluorescent (IF), and Western Blot (WB). To observe the changes of PIPP levels, we used the inhibitors against pAkt1 (Ser473) or PKCδ, SH-6 or sotrastaurin with low and/or high-dose, treated GV oocytes and cultured for 4 h, respectively. The results showed that PIPP expression was significantly enhanced when oocytes were treated with SH-6 or sotrastaurin 10 μM, but decreased with SH-6 or sotrastaurin 100 μM. We also examined the changes of PIPP levels when GV oocytes were treated with exogenous PtdIns(3,4,5)P

Indexed as

HormesisAnimalsCell Cycle CheckpointsCell Cycle ProteinsCell ShapeChromonesDown-RegulationInositol Polyphosphate 5-PhosphatasesMeiotic Prophase IMiceMorpholinesOocytesPhosphatidylinositol PhosphatesPhosphorylationProlineProtein Kinase C-delta2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneCell Cycle ProteinsChromonesInositol Polyphosphate 5-PhosphatasesMorpholinesphosphatidylinositol 3,4,5-triphosphatePhosphatidylinositol PhosphatesProlineProtein Kinase C-deltaProto-Oncogene Proteins c-aktHormesisMouse oocytePhosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P 3)Proline-rich inositol polyphosphate 5-phosphatase (PIPP)Protein kinase Balpha (PKBα/Akt1)

Identifiers

PMID33537929
OpenAlexW3126322037

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.