Evidence map›Paper›PMID 33537925›Full record

ArticleAnnals of biomedical engineering2021

In Vivo Intravascular Pacing Using a Wireless Microscale Stimulator.

Parinaz Abiri, Sandra Duarte-Vogel, Tzu-Chieh Chou, Arash Abiri, Varun Gudapati, Alireza Yousefi, Mehrdad Roustaei, Chih-Chiang Chang, Qingyu Cui, Jeffrey J Hsu and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. A PARYLENE-BASED MEMS INTRAVASCULAR IMPLANT FOR WIRELESS CARDIAC PACING.Proceedings. IEEE International Conference on Micro Electro Mechanical Systems · 2024
    Article
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Parinaz AbiriDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0002-0520-6863
Sandra Duarte-VogelDivision of Laboratory Animal Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Tzu-Chieh ChouDepartment of Medical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Arash AbiriSchool of Medicine, University of California, Irvine, Irvine, CA, 92697, USA.
Varun GudapatiDepartment of Cardiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Alireza YousefiDepartment of Electrical Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Mehrdad RoustaeiDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Chih-Chiang ChangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Qingyu CuiDepartment of Cardiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Jeffrey J HsuDepartment of Cardiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Malcolm BersohnDepartment of Cardiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Dejan MarkovicDepartment of Electrical Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Jun ChenDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Yu-Chong TaiDepartment of Medical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Tzung K HsiaiDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA. THsiai@mednet.ucla.edu.
University of California, Los Angeles · USCalifornia Institute of Technology · USUniversity of California, Irvine · US

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Shear Stress and Light-Sheets to Study Cardiac TrabeculationR01HL129727 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, MARSDEN, ALISON L · 2015 to 2024
$3.5M
Electronica Impedance to Access Metabolically Active PlaqueR01HL118650 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K · 2014 to 2022
$3.3M
Micro-Sensors to Study Electrical and Mechanical Coupling of Injured MyocardiumR01HL111437 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K, XU, XIAOLEI · 2012 to 2020
$3.1M
The effects of androgens on calcium homeostasis in card*K01HL004356 · NHLBI · WAYNE STATE UNIVERSITY · PI GOLDEN, KISH L · 2001 to 2004
$392k
NHLBI NIH HHS BX004356NHLBI NIH HHS EB0220002NHLBI NIH HHS HL111437NHLBI NIH HHS HL118650NHLBI NIH HHS HL129727NIGMS NIH HHS GM008042
6 · The paper itself

Abstract

Millions of patients worldwide are implanted with permanent pacemakers for the treatment of cardiac arrhythmias and conduction disorders. The increased use of these devices has established a growing clinical need to mitigate associated complications. Pacemaker leads, in particular, present the primary risks in most implants. While wireless power transfer holds great promise in eliminating implantable device leads, anatomical constraints limit efficient wireless transmission over the necessary operational range. We thereby developed a transmitter-centered control system for wireless power transfer with sufficient power for continuous cardiac pacing. Device safety was validated using a computational model of the system within an MRI-based anatomical model. The pacer was then fabricated to meet the acute constraints of the anterior cardiac vein (ACV) to enable intravascular deployment while maintaining power efficiency. Our computational model revealed the wireless system to operate at > 50 times below the tissue energy absorption safety criteria. We further demonstrated the capacity for ex vivo pacing of pig hearts at 60 beats per minute (BPM) and in vivo pacing at 120 BPM following pacer deployment in the ACV. This work thus established the capacity for wireless intravascular pacing with the potential to eliminate complications associated with current lead-based deep tissue implants.

Indexed as

Cardiac Pacing, ArtificialPacemaker, ArtificialAnimalsElectric Power SuppliesHumansMaleModels, AnatomicSwineWireless TechnologyCardiovascular devicesImplantable pacemakerLeadless pacemakerWireless biomedical devicesWireless pacemakerWireless power transfer

Identifiers

PMID33537925
OpenAlexW3126470947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.