Evidence map›Paper›PMID 33537921›Full record

ArticleDigestive diseases and sciences2021

Novel Case Report: A Previously Reported, but Pathophysiologically Unexplained, Association Between Collagenous Colitis and Protein-Losing Enteropathy May Be Explained by an Undetected Link with Collagenous Duodenitis.

Inayat Gill, Aciel Ahmed Shaheen, Ahmed Iqbal Edhi, Mitual Amin, Ketan Rana, Mitchell S Cappell

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Inayat GillDivision of Gastroenterology, Department of Internal Medicine, William Beaumont Hospital at Royal Oak, 3535 W. Thirteen Mile Rd, Royal Oak, MI, 48073, USA.ORCID 0000-0001-5972-700X
Aciel Ahmed ShaheenDivision of Gastroenterology, Department of Internal Medicine, William Beaumont Hospital at Royal Oak, 3535 W. Thirteen Mile Rd, Royal Oak, MI, 48073, USA.ORCID 0000-0003-2980-8102
Ahmed Iqbal EdhiDivision of Gastroenterology, Department of Internal Medicine, William Beaumont Hospital at Royal Oak, 3535 W. Thirteen Mile Rd, Royal Oak, MI, 48073, USA.ORCID 0000-0002-9193-1462
Mitual AminDepartment of Pathology, William Beaumont Hospital at Royal Oak, 3600 W. Thirteen Mile Rd, Royal Oak, MI, 48073, USA.ORCID 0000-0002-0558-2615
Ketan RanaDivision of Gastroenterology, Department of Internal Medicine, William Beaumont Hospital at Royal Oak, 3535 W. Thirteen Mile Rd, Royal Oak, MI, 48073, USA.ORCID 0000-0002-4019-9013
Mitchell S CappellDivision of Gastroenterology, Department of Internal Medicine, William Beaumont Hospital at Royal Oak, 3535 W. Thirteen Mile Rd, Royal Oak, MI, 48073, USA. mitchell.cappell@beaumont.edu.ORCID 0000-0003-3445-5428
Beaumont Hospital, Royal Oak · USOakland University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Collagenous colitis (CC) is associated with non-bloody, watery diarrhea, which is pathophysiologically reasonable because normal colonic absorption (or excretion) of water and electrolytes can be blocked by the abnormally thick collagen layer in CC. However, CC has also been associated with six previous cases of protein-losing enteropathy (PLE), with no pathophysiologic explanation. The colon does not normally absorb (or excrete) amino acids/proteins, which is primarily the function of the small bowel. Collagenous duodenitis (CD) has not been associated with PLE. This work reports a novel case of CD (and CC) associated with PLE; a pathophysiologically reasonable mechanism for CD causing PLE (by the thick collagen layer of CD blocking normal intestinal amino acid absorption); and a novel association of PLE with severe COVID-19 infection (attributed to relative immunosuppression from hypoproteinemia, hypoalbuminemia, hypogammaglobulinemia, and malnutrition from PLE).

Indexed as

Intestinal AbsorptionAgedAmino AcidsColitis, CollagenousCOVID-19COVID-19 Drug TreatmentDuodenitisDuodenumFemaleFluid TherapyGlucocorticoidsHumansIntestinal MucosaNutritional StatusParenteral Nutrition, TotalProtein-Losing EnteropathiesAmino AcidsGlucocorticoidsAnasarcaCollagenous colitisCollagenous duodenitisCOVID-19 infectionHypoalbuminemiaMalnutritionProtein-losing enteropathySARS-CoV-2 infection

Identifiers

PMID33537921
PMCPMC7857935
OpenAlexW3128593702

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.