ArticleInfection2021
Torque Teno Virus plasma level as novel biomarker of retained immunocompetence in HIV-infected patients.
Article in Infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Systematic review and meta-analysis of virome profiles and quantification of Torque teno virus load in blood of acute febrile illness patients.Scientific reports · 2025Pooled it
- Torque teno virus as a marker of immune status in immunocompromised patients: A systematic review.European journal of clinical investigation · 2025Pooled it
- A novel Torque teno virus qPCR assay reveals longitudinal viral load variability among non-immunosuppressed subjects.EMBO molecular medicine · 2026Article
- Torque Teno Virus (TTV) Plasma Load and Immune Reconstitution in People Living with HIV: A Systematic Review.Microorganisms · 2026Review
- The Human Virome in Infectious Diseases: Insights from Chronic and Acute Infections Across Body Sites-A Narrative Review.Microorganisms · 2026Review
- Atypical HIV-1 Viremia Persistently Detected Exclusively Through the Pol Target by a Dual-Target (Pol and LTR) Assay: A Case Report About a New Diagnostic Challenge.International journal of molecular sciences · 2026Article
- Anelloviruses: From General Biology to Their Role as Biomarkers of Immune Competence in HIV Infection.Viruses · 2026Review
- The Human Virome in Health and Its Remodeling During HIV Infection and Antiretroviral Therapy: A Narrative Review.Microorganisms · 2025Review
- Longitudinal cervicovaginal bacteriome and virome alterations associate with discordant shedding and ART duration in women living with HIV in Peru.Nature communications · 2025Article
- Anellovirus species in the serum of acute febrile patients from Mato Grosso, central Western Brazil, 2019.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Torque teno virus: a potential marker of immune reconstitution in youths with vertically acquired HIV.Scientific reports · 2024Observational
- Alterations of the gut microbiome in HIV infection highlight human anelloviruses as potential predictors of immune recovery.Microbiome · 2024Article
- HIV-1 diversity in viral reservoirs obtained from circulating T-cell subsets during early ART and beyond.PLoS pathogens · 2024Article
- Torque Teno Virus Load Is Associated With Centers for Disease Control and Prevention Stage and CD4+ Cell Count in People Living With Human Immunodeficiency Virus but Seems Unrelated to AIDS-Defining Events and Human Pegivirus Load.The Journal of infectious diseases · 2024Article
- Torque Teno Virus: A Promising Biomarker in Kidney Transplant Recipients.International journal of molecular sciences · 2024Article
- Torquetenovirus from bronchoalveolar lavage fluid as a biomarker for lung infection among immunocompromised hosts.Biomarkers in medicine · 2024Article
- Exploring the Human Virome: Composition, Dynamics, and Implications for Health and Disease.Current microbiology · 2023Review
- Kinetics of TTV Loads in Peripheral Blood Mononuclear Cells of Early Treated Acute HIV Infections.Viruses · 2023Article
- Understanding torquetenovirus (TTV) as an immune marker.Frontiers in medicine · 2023Review
- Quantification of Torque Teno Virus (TTV) in plasma and saliva of individuals with liver cirrhosis: a cross sectional study.Frontiers in medicine · 2023Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo predict the course of immune recovery (IR) in HIV-1-infected patients after initiation of combined antiretroviral therapy (cART) by determination of the plasma concentration of Torque Teno Virus (TTV). TTV has been identified as marker for risk assessment in immunosuppressed patients after transplantation procedures. Here, TTV was analyzed in HIV-1-infected therapy-naïve patients to evaluate its use as predictor of the course of IR for guidance of individualized treatment.
methodsTTV DNA was quantified in plasma samples of 301 therapy-naïve HIV-1-infected patients and correlated to CD4
resultsTTV DNA was detectable in 96% of the patients' plasma samples with a median TTV plasma concentration of 5.37 log
conclusionWithin the cohort, the significantly elevated TTV plasma concentration in patients with diminished CD4
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.