Evidence map›Paper›PMID 33537757›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2021

In Men With Obesity, T2DM Is Associated With Poor Trabecular Microarchitecture and Bone Strength and Low Bone Turnover.

Francesca Vigevano, Giulia Gregori, Georgia Colleluori, Rui Chen, Vimlin Autemrongsawat, Nicola Napoli, Clifford Qualls, Dennis T Villareal, Reina Armamento-Villareal

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 54 citations in OpenAlex.

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  8. Beneficial effects ofPharmaceutical biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Francesca VigevanoDivision of Endocrinology, Diabetes and Metabolism at Baylor College of Medicine, Houston, TX, USA.
Giulia GregoriDivision of Endocrinology, Diabetes and Metabolism at Baylor College of Medicine, Houston, TX, USA.
Georgia ColleluoriDivision of Endocrinology, Diabetes and Metabolism at Baylor College of Medicine, Houston, TX, USA.
Rui ChenDivision of Endocrinology, Diabetes and Metabolism at Baylor College of Medicine, Houston, TX, USA.
Vimlin AutemrongsawatDivision of Endocrinology, Diabetes and Metabolism at Baylor College of Medicine, Houston, TX, USA.
Nicola NapoliWashington University School of Medicine, St. Louis, MO, USA.
Clifford QuallsBiomedical Research Institute of New Mexico, Albuquerque, NM, USA.
Dennis T VillarealDivision of Endocrinology, Diabetes and Metabolism at Baylor College of Medicine, Houston, TX, USA.
Reina Armamento-VillarealDivision of Endocrinology, Diabetes and Metabolism at Baylor College of Medicine, Houston, TX, USA.
Michael E. DeBakey VA Medical Center · USUniversity of New Mexico · USWashington University in St. Louis · US

Funding

Aromatase Inhibitors and Weight Loss in Severely Obese Men with HypogonadismR01HD093047 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI VILLAREAL, REINA C · 2017 to 2022
$1.9M
NICHD NIH HHS R01 HD093047
6 · The paper itself

Abstract

introductionObesity and type 2 Diabetes (T2D) are both associated with greater bone mineral density (BMD) but increased risk of fractures. The effect of the combination of both conditions on bone metabolism, microarchitecture, and strength in the obese population remains unknown.

methodsData from 112 obese men were collected. Bone turnover and biochemical markers were measured by enzyme-linked immunosorbent assay, body composition and BMD at all sites were assessed by dual energy X-ray absorptiometry, whereas bone microarchitecture and strength (stiffness and failure load) were measured by high-resolution peripheral computed tomography. Data were compared among metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO) with and without T2D and between obese without and with T2D.

resultsCompared to MHO and MUHO without T2D, MUHO with T2D had significantly lower levels of osteocalcin ((7.49 ± 3.0 and 6.03 ± 2.47 vs 4.24 ± 2.72 ng/mL, respectively, P = 0.003) and C-terminal telopeptide of type I collagen (CTx) (0.28 ± 0.10 and 0.29 ± 0.13 vs 0.21 ± 0.15 ng/mL, respectively, P = 0.02). Dividing our subjects simply into those with and without T2D showed that obese men with T2D had significantly lower levels of osteocalcin (P = 0.003) and CTx (P = 0.005), greater trabecular separation at the tibia and radius (P = 0.03 and P = 0.04, respectively), and lower tibial failure load and stiffness (both P = 0.04), relative to obese men without T2D.

conclusionIn men, the combination of obesity and T2D is associated with reduced bone turnover and poorer trabecular bone microarchitecture and bone strength compared to those who are obese but without T2D, suggesting worse bone disease.

Indexed as

Absorptiometry, PhotonAdultAgedBone and BonesBone DensityBone RemodelingDiabetes Mellitus, Type 2Flexural StrengthFollow-Up StudiesHumansHypogonadismMaleMiddle AgedObesityOsteoporosisRisk Factorsbone microarchitecturediabetes mellitusobesityosteoporosis

Identifiers

PMID33537757
PMCPMC8063237
OpenAlexW3127852581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.