ArticleBone & joint open2021
Gentamicin pre-soaking of hamstring autografts decreases infection rates in anterior cruciate ligament reconstruction.
Article in Bone & joint open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Risk Factors for Infection After Ankle, Knee, Hip, Shoulder, or Elbow Arthroscopy: A Systematic Review and Meta-analysis.The American journal of sports medicine · 2026Pooled it
- Biomechanical Analysis of Antibiotic-Treated Tendon Grafts With Digital Image Correlation: A Comparison Between Vancomycin, Gentamycin, and Tobramycin Soaking Techniques.Orthopaedic journal of sports medicine · 2026Article
- Septic arthritis or adult-onset still's disease: analyzing the causes of recurrent fever after arthroscopic combined anterior cruciate ligament and posterior cruciate ligament reconstruction: a case report.BMC musculoskeletal disorders · 2025Article
- No significant difference in skin contamination during anterior cruciate ligament reconstruction with and without preoperative skin cleaning.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Mechanical Properties of Tibialis Tendon Grafts Are Unchanged by Soaking in Tobramycin.Orthopaedic journal of sports medicine · 2025Article
- In Vitro Study of Gentamicin Elution from Tendon Grafts.Indian journal of orthopaedics · 2023Article
- Postoperative Infection after Anterior Cruciate Ligament Reconstruction: Prevention and Management.Microorganisms · 2022Article
- No difference in postoperative efficacy and safety between autograft and allograft in anterior cruciate ligament reconstruction: a retrospective cohort study in 112 patients.Annals of translational medicine · 2022Article
- Septic Arthritis Complicating Arthroscopic Anterior Cruciate Ligament Reconstruction: An Experience from a Tertiary-Care Hospital.Infection and drug resistance · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsGraft infection following anterior cruciate ligament reconstruction (ACLR) may lead to septic arthritis requiring multiple irrigation and debridement procedures, staged revision operations, and prolonged courses of antibiotics. To our knowledge, there are no previous studies reporting on how gentamicin pre-soaking of hamstring grafts influences infection rates following ACLR. We set out to examine this in our study accordingly.
methodsThis retrospective study included 2,000 patients (1,156 males and 844 females) who underwent primary ACLR with hamstring autografts between 2007 to 2017. This included 1,063 patients who received pre-soaked saline hamstring grafts for ACLR followed by 937 patients who received pre-soaked gentamicin hamstring grafts for ACLR. All operative procedures were completed by a single surgeon using a standardized surgical technique. Medical notes were reviewed and data relating to the following outcomes recorded: postoperative infection, clinical progress, causative organisms, management received, and outcomes.
resultsSuperficial wound infection developed in 14 patients (1.31 %) receiving pre-saline soaked hamstring grafts compared to 13 patients (1.38 %) receiving pre-gentamicin soaked hamstring grafts, and this finding was not statistically significant (p = 0.692). All superficial wound infections were treated with oral antibiotics with no further complications. There were no recorded cases of septic arthritis in patients receiving pre-gentamicin soaked grafts compared to nine patients (0.85%) receiving pre-saline soaked grafts, which was statistically significant (p = 0.004).
conclusionPre-soaking hamstring autographs in gentamicin does not affect superficial infection rates but does reduce deep intra-articular infection rates compared to pre-soaking hamstring grafts in saline alone. These findings suggest that pre-soaking hamstring autografts in gentamicin provides an effective surgical technique for reducing intra-articular infection rates following ACLR.Cite this article:
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