ArticleResearch and practice in thrombosis and haemostasis2021
Symptomatic subsegmental versus more central pulmonary embolism: Clinical outcomes during anticoagulation.
Article in Research and practice in thrombosis and haemostasis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- Increasing pulmonary artery visibility and diagnostic confidence with ultra-high resolution photon-counting detector CT pulmonary angiography.European radiology · 2026Article
- Association of advanced therapies for intermediate- to high-risk pulmonary embolism with improved right ventricular function on outpatient follow-up among survivors.Frontiers in cardiovascular medicine · 2026Article
- Personalized anticoagulant therapy in venous thromboembolism: current role of direct oral anticoagulants, unmet clinical needs, and future perspectives on Factor XI inhibition.Frontiers in pharmacology · 2026Review
- Dual-layer dual-energy CT characterization of thrombus composition in acute pulmonary embolism and chronic thromboembolic pulmonary hypertension.The international journal of cardiovascular imaging · 2025Article
- COVID-19: A Disease Driven by Protease/Antiprotease Imbalance? A Specific Review Five Years into the Pandemic.Infection and drug resistance · 2025Review
- Enhanced classification performance using deep learning based segmentation for pulmonary embolism detection in CT angiography.Heliyon · 2024Article
- Detection of acute pulmonary embolism using native repeated magnetic resonance imaging acquisitions under free-breathing and without respiratory or cardiac gating. A diagnostic accuracy study.European journal of radiology open · 2024Article
- Prevalence of and Eligibility for Surveillance Without Anticoagulation Among Adults With Lower-Risk Acute Subsegmental Pulmonary Embolism.JAMA network open · 2023Article
- Clinical Significance and Outcome in Patients with Asymptomatic Versus Symptomatic Subsegmental Pulmonary Embolism.Journal of clinical medicine · 2023Article
- A multicentre observational study of the prevalence, management, and outcomes of subsegmental pulmonary embolism.Journal of thrombosis and thrombolysis · 2023Observational
- Influence of using recommended radiological criteria on MDCT-angiography diagnosis of single isolated subsegmental pulmonary embolism.European radiology · 2022Article
- Challenges in Managing Isolated Subsegmental Pulmonary Embolism.The Permanente journal · 2021Article
- Incidence and clinical profile of venous thromboembolism in hospitalized COVID-19 patients from Madrid region.Thrombosis research · 2021Article
- Clinical significance of subsegmental pulmonary embolism: An ongoing controversy.Research and practice in thrombosis and haemostasis · 2021Article
- Symptomatic subsegmental versus more central pulmonary embolism: Clinical outcomes during anticoagulation.Research and practice in thrombosis and haemostasis · 2021Article
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Authors and funding
11 authors at 11 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe optimal therapy of patients with acute subsegmental pulmonary embolism (PE) is controversial.
methodsWe used the RIETE (Registro Informatizado Enfermedad TromboEmbólica) database to compare the rate of symptomatic PE recurrences during anticoagulation in patients with subsegmental, segmental, or more central PEs.
resultsAmong 15 963 patients with a first episode of symptomatic PE, 834 (5.2%) had subsegmental PE, 3797 (24%) segmental, and 11 332 (71%) more central PE. Most patients in all subgroups received initial therapy with low-molecular-weight heparin, and then most switched to vitamin K antagonists. Median duration of therapy was 179, 185, and 204 days, respectively. During anticoagulation, 183 patients developed PE recurrences, 131 developed deep vein thrombosis (DVT), 543 bled, and 1718 died (fatal PE, 135). The rate of PE recurrences was twofold higher in patients with subsegmental PE than in those with segmental (hazard ratio [HR], 2.13; 95% confidence interval [CI], 1.16-3.85) or more central PE (HR, 1.89; 95% CI, 1.12-3.13). On multivariable analysis, patients with subsegmental PE had a higher risk for PE recurrences than those with central PE (adjusted HR, 1.75; 95% CI, 1.02-3.03). After stratifying patients with subsegmental PE according to ultrasound imaging in the lower limbs, the rate of PE recurrences was similar in patients with DVT, in patients without DVT, and in those with no ultrasound imaging.
conclusionsOur study reveals that the risk for PE recurrences in patients with segmental PE is not lower than in those with more central PE, thus suggesting that the risk of PE recurrences is not influenced by the anatomic location of PE.
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