ArticleResearch and practice in thrombosis and haemostasis2021
Murine cadherin-6 mediates thrombosis in vivo in a platelet-independent manner.
Article in Research and practice in thrombosis and haemostasis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Regulation of fibroblast-like synoviocyte function by cadherin 6 in rheumatoid arthritis.Arthritis research & therapy · 2025Article
- Anti-PD-L1 therapy altered inflammation but not survival in a lethal murine hepatitis virus-1 pneumonia model.Frontiers in immunology · 2023Article
- Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study.Turkish journal of obstetrics and gynecology · 2022Article
- Murine cadherin-6 mediates thrombosis in vivo in a platelet-independent manner.Research and practice in thrombosis and haemostasis · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPlatelet adhesion is the critical process mediating stable thrombus formation. Previous reports of cadherin-6 on human platelets have demonstrated its role in platelet aggregation and thrombus formation.
objectivesWe aimed to further characterize the importance of cadherin-6 in thrombosis in vivo.
methodsCadherin-6 platelet expression was evaluated by western blotting, flow cytometry, and immunoprecipitation. Thrombosis was evaluated using the FeCl
resultsHuman platelet expression of cadherin-6 was confirmed at ~3000 copies per platelet.
conclusionsCadherin-6 plays an essential role in thrombosis in vivo. However, cadherin-6 is not expressed on murine platelets. These data are in contrast to human platelets, which express a functional cadherin-6/catenin complex. The essential, platelet-independent role for cadherin-6 in hemostasis may allow it to be an effective and safe therapeutic target.
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