Evidence map›Paper›PMID 33537510›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

Parabrachial complex processes dura inputs through a direct trigeminal ganglion-to-parabrachial connection.

Olivia Uddin, Michael Anderson, Jesse Smith, Radi Masri, Asaf Keller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. A Tac1-Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Parabrachial Nucleus Activity in Nociception and Pain in Awake Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  6. Parabrachial nucleus activity in nociception and pain in awake mice.bioRxiv : the preprint server for biology · 2023
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Olivia UddinDepartment of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, United States.
Michael AndersonDepartment of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, United States.
Jesse SmithDepartment of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, United States.
Radi MasriDepartment of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, United States.
Asaf KellerDepartment of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, United States.

Funding

Parabrachial role in chronic painR01NS099245 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KELLER, ASAF, MASRI, RADI · 2017 to 2021
$2.2M
NINDS NIH HHS R01 NS099245
6 · The paper itself

Abstract

Migraines cause significant disability and contribute heavily to healthcare costs. Irritation of the meninges' outermost layer (the dura mater), and trigeminal ganglion activation contribute to migraine initiation. Maladaptive changes in central pain-processing regions are also important in maintaining pain. The parabrachial complex (PB) is a central region that mediates chronic pain. PB receives diverse sensory information, including a direct input from the trigeminal ganglion. We hypothesized that PB processes inputs from the dura. Using

Indexed as

CTB, cholera Toxin BFG, FluoroGoldMigrainePainParabrachialPB, parabrachial complexTG, trigeminal ganglionTrigeminal

Identifiers

PMID33537510
PMCPMC7840999

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.