ArticleFrontiers in nutrition2020
Sucralose Stimulates Mitochondrial Bioenergetics in Caco-2 Cells.
Article in Frontiers in nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Mutual Influence of Sucralose and Bisphenol A on Biological and Neurobehavioral Action inInternational journal of molecular sciences · 2026Article
- Biological and Behavioral Responses ofInternational journal of molecular sciences · 2025Article
- Review
- Sucralose-Enhanced Adipogenesis on Preadipocyte Human Cell Line During Differentiation Process.International journal of molecular sciences · 2024Article
- Phenolic Fractions from Walnut Milk Residue: Antioxidant Activity and Cytotoxic Potential.Plants (Basel, Switzerland) · 2024Article
- Sucralose consumption ameliorates high-fat diet-induced glucose intolerance and liver weight gain in mice.Frontiers in nutrition · 2022Article
- Vitamin K Vitamers Differently Affect Energy Metabolism in IPEC-J2 Cells.Frontiers in molecular biosciences · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
Sucralose is a non-caloric artificial sweetener widely used in processed foods that reportedly affects energy homeostasis through partially understood mechanisms. Mitochondria are organelles fundamental for cellular bioenergetics that are closely related to the development of metabolic diseases. Here, we addressed whether sucralose alters mitochondrial bioenergetics in the enterocyte cell line Caco-2. Sucralose exposure (0.5-50 mM for 3-24 h) increased cellular reductive power assessed through MTT assay, suggesting enhanced bioenergetics. Low doses of sucralose (0.5 and 5 mM) for 3 h stimulated mitochondrial respiration, measured through oxygraphy, and elevated mitochondrial transmembrane potential and cytoplasmic Ca
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