Evidence map›Paper›PMID 33537312›Full record

ArticleFrontiers in cell and developmental biology2020

Vascular Adhesion Protein-1 Determines the Cellular Properties of Endometrial Pericytes.

Seley Gharanei, Katherine Fishwick, Ruban Peter Durairaj, Tianrong Jin, Eleftherios Siamantouras, Kuo-Kang Liu, Anne Straube, Emma S Lucas, Christopher J Weston, Pia Rantakari and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Human embryo implantation.Development (Cambridge, England) · 2023
    Review
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Seley GharaneiWarwick Medical School, University of Warwick, Coventry, United Kingdom.
Katherine FishwickWarwick Medical School, University of Warwick, Coventry, United Kingdom.
Ruban Peter DurairajWarwick Medical School, University of Warwick, Coventry, United Kingdom.
Tianrong JinSchool of Engineering, University of Warwick, Coventry, United Kingdom.
Eleftherios SiamantourasSchool of Engineering, University of Warwick, Coventry, United Kingdom.
Kuo-Kang LiuSchool of Engineering, University of Warwick, Coventry, United Kingdom.
Anne StraubeWarwick Medical School, University of Warwick, Coventry, United Kingdom.
Emma S LucasWarwick Medical School, University of Warwick, Coventry, United Kingdom.
Christopher J WestonCentre for Liver Research & National Institute for Health Research Birmingham Biomedical Research Unit, Level 5 Institute for Biomedical Research, University of Birmingham, Birmingham, United Kingdom.
Pia RantakariMedicity Research Laboratory and Institute of Biomedicine, University of Turku, Turku, Finland.
Marko SalmiMedicity Research Laboratory and Institute of Biomedicine, University of Turku, Turku, Finland.
Sirpa JalkanenMedicity Research Laboratory and Institute of Biomedicine, University of Turku, Turku, Finland.
Jan J BrosensWarwick Medical School, University of Warwick, Coventry, United Kingdom.
Bee Kang TanWarwick Medical School, University of Warwick, Coventry, United Kingdom.
University of Warwick · GBUniversity of Turku · FIMiscarriage Association · GBTommy's · GBUniversity of Birmingham · GB

Funding

Medical Research Council MR/P013538/2Medical Research Council MR/R020981/2Wellcome Trust
6 · The paper itself

Abstract

Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible adhesion molecule and a primary amine oxidase involved in immune cell trafficking. Leukocyte extravasation into tissues is mediated by adhesion molecules expressed on endothelial cells and pericytes. Pericytes play a major role in the angiogenesis and vascularization of cycling endometrium. However, the functional properties of pericytes in the human endometrium are not known. Here we show that pericytes surrounding the spiral arterioles in midluteal human endometrium constitutively express VAP-1. We first characterize these pericytes and demonstrate that knockdown of VAP-1 perturbed their biophysical properties and compromised their contractile, migratory, adhesive and clonogenic capacities. Furthermore, we show that loss of VAP-1 disrupts pericyte-uterine natural killer cell interactions

Indexed as

endometriummesenchymal stem/progenitor cellspericytespregnancyuterine natural killer cellsvascular adhesion protein-1

Identifiers

PMID33537312
PMCPMC7848099
OpenAlexW3124526355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.